Mesoporous silicon: a platform for the delivery of therapeutics

被引：101
作者：
Prestidge, Clive A. [2 ]
Barnes, Timothy J. [2 ]
Lau, Chi-Hian [1 ]
Barnett, Christian [1 ]
Loni, Armando [1 ]
Canham, Leigh [1 ]
机构：
[1] PSIMedica Ltd, CSO, Malvern WR14 3SZ, Worcs, England
[2] Univ S Australia, Ian Wark Res Inst, Adelaide, SA 5001, Australia
来源：
EXPERT OPINION ON DRUG DELIVERY | 2007年 / 4卷 / 02期
基金：
澳大利亚研究理事会;
关键词：
drug delivery; nanostructuring; porous silicon; WATER-SOLUBLE DRUGS; HUMAN SERUM-ALBUMIN; POROUS SILICON; DISSOLUTION; ACID; FORMULATION; FABRICATION; PARTICLES; CHEMISTRY; GERMANIUM;
D O I：
10.1517/17425247.4.2.101
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nanostructuring materials can radically change their proper-ties. Two interesting examples highlighted here are nanoscale porosity inducing biodegradability, and nanoscale confinement affecting the physical form of an entrapped drug. Mesoporous silicon is under increasing study for drug-delivery applications, and is the topic of this review. The authors focus on those proper-ties of most relevance to this application, as well as those recent studies published on small molecule and peptide/protein delivery.
引用
收藏
页码：101 / 110
页数：10
相关论文
共 65 条
  • [1] Dissolution of different forms of partially porous silicon wafers under simulated physiological conditions
    Anderson, SHC
    Elliott, H
    Wallis, DJ
    Canham, LT
    Powell, JJ
    [J]. PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, 2003, 197 (02): : 331 - 335
  • [2] Engineering the chemistry and nanostructure of porous Silicon Fabry-Perot films for loading and release of a steroid
    Anglin, EJ
    Schwartz, MP
    Ng, VP
    Perelman, LA
    Sailor, MJ
    [J]. LANGMUIR, 2004, 20 (25) : 11264 - 11269
  • [3] Galvanic porous silicon formation without external contacts
    Ashruf, CMA
    French, PJ
    Bressers, PMMC
    Kelly, JJ
    [J]. SENSORS AND ACTUATORS A-PHYSICAL, 1999, 74 (1-3) : 118 - 122
  • [4] Birnbaum DT, 2003, CANC DRUG DISC DEV, P117
  • [5] Porous silicon: a quantum sponge structure for silicon based optoelectronics
    Bisi, O
    Ossicini, S
    Pavesi, L
    [J]. SURFACE SCIENCE REPORTS, 2000, 38 (1-3) : 1 - 126
  • [6] Reference values for serum silicon in adults
    Bissé, E
    Epting, T
    Beil, A
    Lindinger, G
    Lang, H
    Wieland, H
    [J]. ANALYTICAL BIOCHEMISTRY, 2005, 337 (01) : 130 - 135
  • [7] Passivated luminescent porous silicon
    Boukherroub, R
    Wayner, DDM
    Lockwood, DJ
    Canham, LT
    [J]. JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 2001, 148 (09) : H91 - H97
  • [8] BULPITT P, 2006, P 33 ANN M EXP CONTR, P849
  • [9] Lewis acid mediated hydrosilylation on porous silicon surfaces
    Buriak, JM
    Stewart, MP
    Geders, TW
    Allen, MJ
    Choi, HC
    Smith, J
    Raftery, D
    Canham, LT
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (49) : 11491 - 11502
  • [10] Organometallic chemistry on silicon and germanium surfaces
    Buriak, JM
    [J]. CHEMICAL REVIEWS, 2002, 102 (05) : 1271 - 1308
1234567