Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems

被引：58

作者：

Manikkath, Jyothsna ^{[1
]}

Subramony, J. Anand ^{[2
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal 576104, Karnataka, India

[2] AstraZeneca, R&D, Biol Engn, Gaithersburg, MD 20878 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2021年 / 179卷

关键词：

Wearables; Skin-interfaced wearables; Wearables for drug delivery; Transdermal drug delivery; Closed-loop drug delivery systems; On-demand drug delivery; Self-powered wearables; Microneedles; COVID-19; MICRONEEDLE PATCH; ON-SKIN; SENSORS; DEVICES; VACCINATION; PERMEATION;

D O I：

10.1016/j.addr.2021.113997

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The recent advancement and prevalence of wearable technologies and their ability to make digital measurements of vital signs and wellness parameters have triggered a new paradigm in the management of diseases. Drug delivery as a function of stimuli or response from wearable, closed-loop systems can offer real-time on-demand or preprogrammed drug delivery capability and offer total management of disease states. Here we review the key opportunities in this space for development of closed-loop systems, given the advent of digital wearable technologies. Particular considerations and focus are given to closed-loop systems combined with transdermal drug delivery technologies. (c) 2021 Published by Elsevier B.V.

引用

页数：17

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