Growing pains: Non-adherence with the immunosuppressive regimen in adolescent transplant recipients

被引:266
|
作者
Dobbels, F
Van Damme-Lombaert, R
Vanhaecke, J
De Geest, S
机构
[1] Katholieke Univ Leuven, Ctr Hlth Serv & Nursing Res, B-3000 Louvain, Belgium
[2] Katholieke Univ Leuven, Sch Med, Univ Hosp Leuven, Heart Transplant Program, Louvain, Belgium
[3] Katholieke Univ Leuven, Sch Med, Univ Hosp Leuven, Pediat Transplant Program, Louvain, Belgium
[4] Univ Basel, Inst Nursing Sci, Basel, Switzerland
关键词
non-adherence; adolescence; behaviour; medication;
D O I
10.1111/j.1399-3046.2005.00356.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
One-year graft and patient survival are better in adolescent transplant recipients (age 11-19 years) than in younger (age < 11 years) pediatric transplant recipients. However, several groups found that long-term outcomes (> i.e. 5 year post-transplant) in the adolescent age group are significantly worse than in younger transplant recipients. A behavioral factor that could explain an important part of the poorer clinical outcome in adolescent transplant recipients is non-compliance with medication taking. Adolescents, like all organ transplant recipients irrespective of their age, must adhere to a life-long immunosuppressive regimen in addition to other aspects of their therapeutic regimen. Therefore, adolescent transplant recipients, as all transplant patients, should be regarded as a chronically ill patient population in whom behavioral and psychosocial management is equally important as state-of-the-art medical management. This paper provides an overview of the current knowledge on prevalence, clinical consequences, and risk-factors for non-compliance with the immunosuppressive regimen in adolescent transplant recipients and offers some suggestions for adolescent-tailored interventions to improve medication adherence.
引用
收藏
页码:381 / 390
页数:10
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