SERS nanoparticles: a new optical detection modality for cancer diagnosis

被引：85

作者：

Sha, Michael Y. ^{[1
]}

Xu, Hongxia ^{[1
]}

Penn, Sharron G. ^{[1
]}

Cromer, Remy ^{[1
]}

机构：

[1] Oxonica Inc, Mountain View, CA 94043 USA

来源：

NANOMEDICINE | 2007年 / 2卷 / 05期

关键词：

diagnostics; HIV; nanoparticles; oncology; Raman; surface-enhanced Raman scattering;

D O I：

10.2217/17435889.2.5.725

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Surface-enhanced Raman scattering. (SERS) is an optical detection technique that offers advantages over traditional assay detection technologies, such as fluorescence and chemiluminescence. These advantages include sensitivity, high levels of multiplexing, robustness and ability to perform detection in blood and other biological matrices. Here, we report on the growing field of SERS-active nanoparticles as a novel method for detection, with special emphasis on their use in the field of oncology. We discuss examples of SERS-active nanoparticles used in an assay for PSA, BRCA1 and Her-2, along with examples of nucleic-acid detection. We present data on a novel homogeneous, single-tube, rapid assay for nucleic acid detection and show how it will benefit the oncology community.

引用

页码：725 / 734

页数：10

共 73 条

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