Extremely low frequency (ELF) magnetic fields and apoptosis: a review

被引:39
作者
Santini, MT
Ferrante, A
Rainaldi, G
Indovina, P
Indovina, PL
机构
[1] Ist Super Sanita, Dipartimento Ematol Oncol & Med Mol, I-00161 Rome, Italy
[2] Complesso Univ Monte S Angelo, Ist Nazl Fis Mat, Unita Napoli, Naples, Italy
[3] Univ Naples Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Fis, Naples, Italy
关键词
sinusoidal magnetic fields (50 Hz); apoptosis; calcium ion;
D O I
10.1080/09553000400029502
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In recent years, there has been increasing evidence that extremely low frequency magnetic fields might be linked to tumours, particularly with childhood leukaemia. In the same period, the role of apoptosis in the tumour process has also gained increasing importance. It is the purpose of this review to describe the apoptotic process, discuss selected papers in which apoptosis is examined in cells exposed to magnetic fields and describe the possible biophysical mechanisms responsible for changes in the apoptotic process in exposed cells. Despite some differences, as a whole, the literature seems to demonstrate that magnetic fields induce changes in apoptosis in cells exposed to different experimental protocols. In addition, the important role of ions, particularly of Ca2+, in the apoptotic process is also discussed, and one possible model for magnetic field action on apoptosis that brings together experimental observations of different nature is suggested and discussed.
引用
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页码:1 / 11
页数:11
相关论文
共 97 条
[1]   Death without caspases, caspases without death [J].
Abraham, MC ;
Shaham, S .
TRENDS IN CELL BIOLOGY, 2004, 14 (04) :184-193
[2]   The Bcl-2 protein family: Arbiters of cell survival [J].
Adams, JM ;
Cory, S .
SCIENCE, 1998, 281 (5381) :1322-1326
[3]   Review of the epidemiologic literature on EMF and health [J].
Ahlbom, A ;
Cardis, E ;
Green, A ;
Linet, M ;
Savitz, D ;
Swerdlow, A .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2001, 109 :911-933
[4]   Apoptosis-independent functions of killer caspases [J].
Algeciras-Schimnich, A ;
Barnhart, BC ;
Peter, ME .
CURRENT OPINION IN CELL BIOLOGY, 2002, 14 (06) :721-726
[5]   SENSITIVITY OF CALCIUM-BINDING IN CEREBRAL TISSUE TO WEAK ENVIRONMENTAL ELECTRIC-FIELDS OSCILLATING AT LOW-FREQUENCY [J].
BAWIN, SM ;
ADEY, WR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :1999-2003
[6]  
Blackman CF, 2001, BIOELECTROMAGNETICS, V22, P122, DOI 10.1002/1521-186X(200102)22:2<122::AID-BEM1015>3.0.CO
[7]  
2-V
[8]   CLARIFICATION AND APPLICATION OF AN ION PARAMETRIC RESONANCE MODEL FOR MAGNETIC-FIELD INTERACTIONS WITH BIOLOGICAL-SYSTEMS [J].
BLANCHARD, JP ;
BLACKMAN, CF .
BIOELECTROMAGNETICS, 1994, 15 (03) :217-238
[9]   Regulation of apoptosis by endoplasmic reticulum pathways [J].
Breckenridge, DG ;
Germain, M ;
Mathai, JP ;
Nguyen, M ;
Shore, GC .
ONCOGENE, 2003, 22 (53) :8608-8618
[10]   Regulation of apoptosis by Bcl-2 family proteins [J].
Burlacu, A .
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2003, 7 (03) :249-257