Anti-IL6R role in treatment of COVID-19-related ARDS

被引：68

作者：

Buonaguro, Franco Maria ^{[1
]}

Puzanov, Igor ^{[2
]}

Ascierto, Paolo Antonio ^{[1
]}

机构：

[1] Ist Nazl Tumori IRCCS Fdn G Pascale, Melanoma Canc Immunotherapy & Dev Therapeut Unit, Via Mariano Semmola, I-80131 Naples, Italy

[2] Roswell Pk Comprehens Canc Ctr, Buffalo, NY USA

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2020年 / 18卷 / 01期

关键词：

COVID-19; SARS-CoV-2; ARDS; IL-6; Tocilizumab;

D O I：

10.1186/s12967-020-02333-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页数：2

共 7 条

[1] Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung [J].

Dienz, O. ;

Rud, J. G. ;

Eaton, S. M. ;

Lanthier, P. A. ;

Burg, E. ;

Drew, A. ;

Bunn, J. ;

Suratt, B. T. ;

Haynes, L. ;

Rincon, M. .

MUCOSAL IMMUNOLOGY, 2012, 5 (03) :258-266

[2] Why tocilizumab could be an effective treatment for severe COVID-19? [J].

Fu, Binqing ;

Xu, Xiaoling ;

Wei, Haiming .

JOURNAL OF TRANSLATIONAL MEDICINE, 2020, 18 (01)

[3]

General Office of National Health Commission General Office of National Administration of Traditional Chinese Medicine, DIAGN TREATM PROT NO

[4] Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology [J].

Lauder, Sarah N. ;

Jones, Emma ;

Smart, Kathryn ;

Bloom, Anja ;

Williams, Anwen S. ;

Hindley, James P. ;

Ondondo, Beatrice ;

Taylor, Philip R. ;

Clement, Mathew ;

Fielding, Ceri ;

Godkin, Andrew J. ;

Jones, Simon A. ;

Gallimore, Awen M. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (10) :2613-2625

[5] Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection [J].

Liu, Li ;

Wei, Qiang ;

Lin, Qingqing ;

Fang, Jun ;

Wang, Haibo ;

Kwok, Hauyee ;

Tang, Hangying ;

Nishiura, Kenji ;

Peng, Jie ;

Tan, Zhiwu ;

Wu, Tongjin ;

Cheung, Ka-Wai ;

Chan, Kwok-Hung ;

Alvarez, Xavier ;

Qin, Chuan ;

Lackner, Andrew ;

Perlman, Stanley ;

Yuen, Kwok-Yung ;

Chen, Zhiwei .

JCI INSIGHT, 2019, 4 (04)

[6] Interleukin-6 is crucial for recall of influenza-specific memory CD4+ T cells [J].

Longhi, Maria Paula ;

Wright, Kate ;

Lauder, Sarah N. ;

Nowell, Mari A. ;

Jones, Gareth W. ;

Godkin, Andrew J. ;

Jones, Simon A. ;

Gallimore, Awen M. .

PLOS PATHOGENS, 2008, 4 (02)

[7] Impact of tocilizumab therapy on antibody response to influenza vaccine in patients with rheumatoid arthritis [J].

Mori, Shunsuke ;

Ueki, Yukitaka ;

Hirakata, Naoyuki ;

Oribe, Motohiro ;

Hidaka, Toshihiko ;

Oishi, Kazunori .

ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (12) :2006-2010

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