Antibiotic susceptibility profiles of anaerobic pathogens in The Netherlands

被引：49

作者：

Veloo, A. C. M. ^{[1
]}

van Winkelhoff, A. J. ^{[1
,2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Med Microbiol, NL-9700 AB Groningen, Netherlands

[2] Dept Dent & Oral Hyg, Groningen, Netherlands

来源：

ANAEROBE | 2015年 / 31卷

关键词：

Antibiotics; Resistance; The Netherlands; ANTIMICROBIAL SUSCEPTIBILITY; RESISTANCE; SURVEILLANCE; BACTERIA;

D O I：

10.1016/j.anaerobe.2014.08.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antibiotic susceptibility profile of the Bacteroides fragilis group, Gram-positive anaerobic cocci (GPAC), Fusobacterium spp., Prevotella spp., Veillonella spp. and Bilophila wadsworthia for amoxicillin, amoxicillin-clavulanic acid, clindamycin and metronidazole was determined. Human clinical isolates were isolated between 2011 and 2013 at the Microbiological Diagnostic Laboratory of the University Medical Center Groningen, The Netherlands and subjected to MALDI-TOF MS identification and susceptibility testing using E-test for MIC determination. Differences in clindamycin susceptibility between species of the B. fragilis group and GPAC were observed, with Bacteroides ovatus and Peptoniphilus harei having the highest resistance rates. Compared to other European countries, in The Netherlands the MIC90 for clindamycin of fusobacteria is low. Metronidazole resistance was first encountered in the genus Prevotella in 2013, but not in species of GPAC as reported in Belgium and Bulgaria. The differences in clindamycin resistance between the different European countries and reports of metronidazole resistance within the genera Prevotella and GPAC warrant more extensive susceptibility studies on anaerobic pathogens. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：19 / 24

页数：6

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