The presence of retraction clefts correlates with lymphovascular invasion and lymph node metastasis and predicts poor outcome: Analysis of 2497 breast cancer patients

被引:4
作者
Li, Weidong [1 ,2 ,8 ,9 ,10 ]
Jia, Hongqin [1 ,2 ,3 ,8 ,9 ,10 ]
Wang, Shuling [4 ,8 ,9 ,10 ]
Guo, Xiaojing [1 ,2 ,8 ,9 ,10 ]
Zhang, Xinmin [5 ]
Zhang, Lanjing [6 ,11 ,12 ]
Wen, Hannah Y. [7 ]
Fu, Li [1 ,2 ,8 ,9 ,10 ]
机构
[1] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Breast Canc Pathol, Tianjin, Peoples R China
[2] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Res Lab, Tianjin, Peoples R China
[3] Fudan Univ, Eye & ENT Hosp, Dept Pathol, Shanghai, Peoples R China
[4] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Dept Breast Oncol, Tianjin, Peoples R China
[5] Rowan Univ, Cooper Univ Hosp, Dept Pathol, Cooper Med Sch, One Cooper Plaza, Camden, NJ USA
[6] Univ Med Ctr Princeton, Dept Pathol, Plainsboro, NJ USA
[7] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10065 USA
[8] Tianjins Clin Res Ctr Canc, Tianjin, Peoples R China
[9] Tianjin Med Univ, Key Lab Breast Canc Prevent & Therapy, Minist Educ, Tianjin, Peoples R China
[10] Key Lab Canc Prevent & Therapy, Dept Chem Biol, Ernest Mario Sch Pharm, Tianjin, NJ, Peoples R China
[11] Rutgers State Univ, Dept Biol Sci, Newark, NJ USA
[12] Rutgers Canc Inst New Jersey, New Brunswick, NJ USA
基金
中国国家自然科学基金;
关键词
Breast cancer; Retraction clefts; Invasive micropapillary carcinoma; Lymphovascular invasion; Lymph node metastasis; NEEDLE CORE BIOPSIES; MICROPAPILLARY CARCINOMA; PERITUMORAL RETRACTION; ARTIFACT; SURVIVAL;
D O I
10.1016/j.anndiagpath.2022.152047
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Some invasive breast carcinomas are surrounded by a clear space that separate the tumor cells from the adjacent stroma, similar to invasive micropapillary carcinoma (IMPC), but lack the thin strands of connective tissue that separate the cells and characteristic "inside-out" growth pattern of IMPC on immunohistochemical stain for EMA. We consider the presence of the retraction clefts a common phenomenon that may present as a precursor stage of IMPC (PSIMPC). In this study, a total of 2497 cases of invasive breast carcinomas were prospectively collected. Among 2497 cases of breast cancer, 949 (38.0 %) cases were PSIMPC, 200 (8.0 %) cases were IMPC and 1348 (54.0 %) cases were IBC-NST. LVI was seen in128 of 200 (64 %) IMPC and 364 of 948 (38.0 %) PSIMPC, in contrast to 246 of 1341 (18 %) IBC-NST (P < 0.001). Lymph node metastasis was seen in 147 of 200 (73.4 %) IMPC and 551 of 949 (58 %) PSIMPC, in contrast to 563 of 1345 (42 %) IBC-NST (P < 0.001). The 5-year disease-free survival (DFS) and overall survival (OS) of PSIMPC were 76.8 % and 87.6 %, compared to 63.2 % and 85.9 % in IMPC, 86.2 % and 93.7 % in IBC-NST. PSIMPC demonstrated a more favorable DFS and OS compared to IMPC, but worse DFS and OS compared to IBC-NST. Cox and logistic regression analysis showed that PSIMPC was an independent predictor of DFS and OS. Our findings suggest that the presence of retraction clefts is a precursor state of IMPC, exhibiting IMPC-like features, such as higher incidence of lymphovascular invasion, lymph node metastasis and more aggressive clinical behavior.
引用
收藏
页数:8
相关论文
共 21 条
[1]   The Presence of Extensive Retraction Clefts in Invasive Breast Carcinomas Correlates With Lymphatic Invasion and Nodal Metastasis and Predicts Poor Outcome A Prospective Validation Study of 2742 Consecutive Cases [J].
Acs, Geza ;
Khakpour, Nazanin ;
Kiluk, John ;
Lee, Marie Catherine ;
Laronga, Christine .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2015, 39 (03) :325-337
[2]   The extent of retraction clefts correlates with lymphatic vessel density and VEGF-C expression and predicts nodal metastasis and poor prognosis in early-stage breast carcinoma [J].
Acs, Geza ;
Paragh, Gyorgy ;
Rakosy, Zsuzsa ;
Laronga, Christine ;
Zhang, Paul J. .
MODERN PATHOLOGY, 2012, 25 (02) :163-177
[3]   Invasive Ductal Carcinomas of the Breast Showing Partial Reversed Cell Polarity are Associated With Lymphatic Tumor Spread and may Represent Part of a Spectrum of Invasive Micropapillary Carcinoma [J].
Acs, Geza ;
Esposito, Nicole N. ;
Rakosy, Zsuzsa ;
Laronga, Christine ;
Zhang, Paul J. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2010, 34 (11) :1637-1646
[4]   The Presence of Micropapillary Features and Retraction Artifact in Core Needle Biopsy Material Predicts Lymph Node Metastasis in Breast Carcinoma [J].
Acs, Geza ;
Paragh, Gyorgy ;
Chuang, Shang-Tian ;
Laronga, Christine ;
Zhang, Paul J. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (02) :202-210
[5]   Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling [J].
Allen, Steven G. ;
Chen, Yu-Chih ;
Madden, Julie M. ;
Fournier, Chelsea L. ;
Altemus, Megan A. ;
Hiziroglu, Ayse B. ;
Cheng, Yu-Heng ;
Wu, Zhi Fen ;
Bao, Liwei ;
Yates, Joel A. ;
Yoon, Euisik ;
Merajver, Sofia D. .
SCIENTIFIC REPORTS, 2016, 6
[6]   Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update [J].
Allison, Kimberly H. ;
Hammond, M. Elizabeth H. ;
Dowsett, Mitchell ;
McKernin, Shannon E. ;
Carey, Lisa A. ;
Fitzgibbons, Patrick L. ;
Hayes, Daniel F. ;
Lakhani, Sunil R. ;
Chavez-MacGregor, Mariana ;
Perlmutter, Jane ;
Perou, Charles M. ;
Regan, Meredith M. ;
Rimm, David L. ;
Symmans, W. Fraser ;
Torlakovic, Emina E. ;
Varella, Leticia ;
Viale, Giuseppe ;
Weisberg, Tracey F. ;
McShane, Lisa M. ;
Wolff, Antonio C. .
JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (12) :1346-+
[7]   Prognostic Markers for Invasive Micropapillary Carcinoma of the Breast: A Population-Based Analysis [J].
Chen, Albert C. ;
Paulino, Arnold C. ;
Schwartz, Mary R. ;
Rodriguez, Angel A. ;
Bass, Barbara L. ;
Chang, Jenny C. ;
Teh, Bin S. .
CLINICAL BREAST CANCER, 2013, 13 (02) :133-139
[8]   Artefact as the pathologist's friend: Peritumoral retraction in in situ and infiltrating duct carcinoma of the breast [J].
Irie, Junji ;
Manucha, Varsha ;
Ioffe, Olga B. ;
Silverberg, Steven G. .
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, 2007, 15 (01) :53-59
[9]   The Impact of Peritumoral Retraction Clefting & Intratumoral Eosinophils on Overall Survival in Oral Squamous Carcinoma Patients [J].
Jain, Dhruv ;
Tikku, Gargi ;
Bhadana, Pallavi ;
Dravid, Chandrashekhar ;
Grover, Rajesh Kumar .
PATHOLOGY & ONCOLOGY RESEARCH, 2019, 25 (01) :183-189
[10]   Periacinar retraction clefting in the prostatic needle core biopsies: an important diagnostic criterion or a simple artifact? [J].
Kruslin, B ;
Tomas, D ;
Rogatsch, H ;
Novosel, I ;
Cupic, H ;
Belicza, M ;
Kraus, O ;
Mikuz, G .
VIRCHOWS ARCHIV, 2003, 443 (04) :524-527