An Empirical Model of End-Tidal CO2 Response to Minute Ventilation

被引：0

作者：

Hahn, Jin-Oh ^{[1
]}

Shrawane, Prasad ^{[1
]}

Dumont, Guy A. ^{[1
]}

Ansermino, J. Mark ^{[2
]}

机构：

[1] Univ British Columbia, Dept Elect & Comp Engn, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Anesthesiol, Vancouver, BC V6T 1Z4, Canada

来源：

2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2010年

关键词：

MECHANICAL VENTILATION; ANESTHESIA; SYSTEM;

D O I：

10.1109/IEMBS.2010.5626059

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper presents an empirical model of end-tidal CO2 (PETCO2) response to minute ventilation (MV) for use in the closed-loop control of artificial respiration. An affine model structure consisting of a linear dynamic system followed by an affine transform is presented. It is proposed that this derives a low-order, high-fidelity representation of the respiratory process that can describe the positive and inversely proportional relationship between PETCO2 and MV. The efficacy of the model is evaluated using experimental respiratory data from 18 human subjects. The model performed well with a root-mean-squared error (RMSE) of 0.22+/-0.15 mmHg and a coefficient of determination (r(2)) of 0.81+/-0.18 (mean+/-SD) when a 2(nd)-order rational transfer function was used as the linear component of the model. The physiologic implication of the model is analyzed by comparison with a traditional compartment model that is widely used in pharmacological modeling.

引用

页码：524 / 527

页数：4

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