Mitochondrially-targeted treatment strategies

被引：47
作者：
Bozi, Luiz H. M. [1 ]
Campos, Juliane C. [1 ]
Zambelli, Vanessa O. [2 ]
Ferreira, Nikolas D. [1 ]
Ferreira, Julio C. B. [1 ,3 ]
机构：
[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo, Brazil
[2] Butantan Inst, Sao Paulo, Brazil
[3] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2020年 / 71卷
基金：
巴西圣保罗研究基金会;
关键词：
Metabolism; Therapy; Oxidative stress; Mitophagy; Cell signaling; Physiology; Patients; ALDEHYDE DEHYDROGENASE 2; UNFOLDED PROTEIN RESPONSE; PROLIFERATOR-ACTIVATED RECEPTOR; HEREDITARY OPTIC NEUROPATHY; PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL NEUROPATHY; PERMEABILITY TRANSITION PORE; PIOGLITAZONE CLINICAL-TRIAL; INDUCED HEART-FAILURE; OXYGEN SPECIES ROS;
D O I：
10.1016/j.mam.2019.100836
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases (mitochondriopathies) and many other infectious and non-infectious diseases including viral, bacterial and protozoan infections, inflammatory and chronic pain, neurodegeneration, diabetes, obesity and cardiovascular diseases. Mitochondria therefore become an attractive target for developing new therapies. In this review we describe critical mechanisms involved in the maintenance of mitochondrial functionality and discuss strategies used to identify and validate mitochondrial targets in different diseases. We also highlight the most recent preclinical and clinical findings using molecules targeting mitochondrial bioenergetics, morphology, number, content and detoxification systems in common pathologies.
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页数：21
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