Mitochondrially-targeted treatment strategies

被引：47
作者：
Bozi, Luiz H. M. [1 ]
Campos, Juliane C. [1 ]
Zambelli, Vanessa O. [2 ]
Ferreira, Nikolas D. [1 ]
Ferreira, Julio C. B. [1 ,3 ]
机构：
[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo, Brazil
[2] Butantan Inst, Sao Paulo, Brazil
[3] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2020年 / 71卷
基金：
巴西圣保罗研究基金会;
关键词：
Metabolism; Therapy; Oxidative stress; Mitophagy; Cell signaling; Physiology; Patients; ALDEHYDE DEHYDROGENASE 2; UNFOLDED PROTEIN RESPONSE; PROLIFERATOR-ACTIVATED RECEPTOR; HEREDITARY OPTIC NEUROPATHY; PLACEBO-CONTROLLED TRIAL; INDUCED PERIPHERAL NEUROPATHY; PERMEABILITY TRANSITION PORE; PIOGLITAZONE CLINICAL-TRIAL; INDUCED HEART-FAILURE; OXYGEN SPECIES ROS;
D O I：
10.1016/j.mam.2019.100836
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Disruption of mitochondrial function is a common feature of inherited mitochondrial diseases (mitochondriopathies) and many other infectious and non-infectious diseases including viral, bacterial and protozoan infections, inflammatory and chronic pain, neurodegeneration, diabetes, obesity and cardiovascular diseases. Mitochondria therefore become an attractive target for developing new therapies. In this review we describe critical mechanisms involved in the maintenance of mitochondrial functionality and discuss strategies used to identify and validate mitochondrial targets in different diseases. We also highlight the most recent preclinical and clinical findings using molecules targeting mitochondrial bioenergetics, morphology, number, content and detoxification systems in common pathologies.
引用
收藏
页数：21
相关论文
共 386 条
  • [1] Mitochondrial complex IV deficiency, caused by mutated COX6B1, is associated with encephalomyopathy, hydrocephalus and cardiomyopathy
    Abdulhag, Ulla Najwa
    Soiferman, Devorah
    Schueler-Furman, Ora
    Miller, Chaya
    Shaag, Avraham
    Elpeleg, Orly
    Edvardson, Simon
    Saada, Ann
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 2015, 23 (02) : 159 - 164
  • [2] Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial
    Abe, Koji
    Aoki, Masashi
    Tsuji, Shoji
    Itoyama, Yasuto
    Sobue, Gen
    Togo, Masanori
    Hamada, Chikuma
    Tanaka, Masahiko
    Akimoto, Makoto
    Nakamura, Kazue
    Takahashi, Fumihiro
    Kondo, Kazuoki
    Yoshino, Hiide
    [J]. LANCET NEUROLOGY, 2017, 16 (07) : 505 - 512
  • [3] Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury
    Adlam, VJ
    Harrison, JC
    Porteous, CM
    James, AM
    Smith, RAJ
    Murphy, MP
    Sammut, IA
    [J]. FASEB JOURNAL, 2005, 19 (09) : 1088 - 1095
  • [4] Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
    Ahlqvist, Kati J.
    Hamalainen, Riikka H.
    Yatsuga, Shuichi
    Uutela, Marko
    Terzioglu, Mugen
    Gotz, Alexandra
    Forsstrom, Saara
    Salven, Petri
    Angers-Loustau, Alexandre
    Kopra, Outi H.
    Tyynismaa, Henna
    Larsson, Nils-Goran
    Wartiovaara, Kirmo
    Prolla, Tomas
    Trifunovic, Aleksandra
    Suomalainen, Anu
    [J]. CELL METABOLISM, 2012, 15 (01) : 100 - 109
  • [5] Diagnosis and Treatment of Mitochondrial Myopathies
    Ahmed, Syeda T.
    Craven, Lyndsey
    Russell, Oliver M.
    Turnbull, Doug M.
    Vincent, Amy E.
    [J]. NEUROTHERAPEUTICS, 2018, 15 (04) : 943 - 953
  • [6] Discovery of Genes Activated by the Mitochondrial Unfolded Protein Response (mtUPR) and Cognate Promoter Elements
    Aldridge, Jonathan E.
    Horibe, Tomohisa
    Hoogenraad, Nicholas J.
    [J]. PLOS ONE, 2007, 2 (09):
  • [7] The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
    Anand, Ruchika
    Wai, Timothy
    Baker, Michael J.
    Kladt, Nikolay
    Schauss, Astrid C.
    Rugarli, Elena
    Langer, Thomas
    [J]. JOURNAL OF CELL BIOLOGY, 2014, 204 (06) : 919 - 929
  • [8] Pharmacological approaches to restore mitochondrial function
    Andreux, Penelope A.
    Houtkooper, Riekelt H.
    Auwerx, Johan
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2013, 12 (06) : 465 - 483
  • [9] Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
    Anello, M
    Lupi, R
    Spampinato, D
    Piro, S
    Masini, M
    Boggi, U
    Del Prato, S
    Rabuazzo, AM
    Purrello, F
    Marchetti, P
    [J]. DIABETOLOGIA, 2005, 48 (02) : 282 - 289
  • [10] [Anonymous], ELIFE
12345678910