Primary role of mitochondria and calcium ions in the induction of reactive oxygen species by external stimuli such as triorganotins

Tributyltin (TBT) salts are potent skin irritants both in humans and rodents. Data in the literature indicate mitochondria as target of TBT effects. The purpose of this study was to investigate the early intracellular molecular events that follow TBT treatment and mitochondrial impairment and the relevance of mitochondria in gene-regulatory signalling pathways. The results obtained indicate the pivotal role of Ca2+ as the starting event following TBT treatment and confirm the important role of mitochondria as the source of second messenger molecules essential for TBT-induced NF-kappa B activation and IL-1 alpha production. (C) 1995 Elsevier Science Ltd All rights reserved.