Evaluation of biological activities of cobalt(II) and copper(II) complexes synthesized from methylcarboxylate and amino alcohol ligand mixtures: spectroscopic, structural and docking studies

被引：1
作者：
Esmaeilzadeh, Javad [1 ]
Mardani, Zahra [1 ]
Golsanamlou, Vali [1 ]
Moeini, Keyvan [2 ]
Krautscheid, Harald [3 ]
机构：
[1] Urmia Univ, Fac Chem, Inorgan Chem Dept, Orumiyeh, Iran
[2] Payame Noor Univ, Dept Chem, Tehran 193954697, Iran
[3] Univ Leipzig, Inst Anorgan Chem, Leipzig, Germany
来源：
INORGANIC AND NANO-METAL CHEMISTRY | 2023年 / 53卷 / 10期
关键词：
Pyridine-2; 6-dicarboxylate; amino alcohol; cobalt; copper; docking study; DFT; SCHIFF-BASE LIGAND; ANTICANCER ACTIVITIES; DIPICOLINIC ACID; CRYSTAL-STRUCTURES; DIMETHYL PYRIDINE-2,6-DICARBOXYLATE; SOLID-STATE; COORDINATION; CADMIUM(II); CO(II); NI(II);
D O I：
10.1080/24701556.2021.1980033
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two cobalt(II) and copper(II) complexes, [Co-2(PDCA)(mu-PDCA)(H2O)(5)]center dot 2H(2)O (1); H(2)PDCA: pyridine-2,6-dicarboxylic acid and [Cu(DEA)(PDCA)] (2); DEA: diethanolamine, were prepared from a mixed ligand amine/PDCA methyl ester mixture and identified by elemental analysis, FT-IR spectroscopy and single-crystal X-ray diffraction. X-ray structure analysis of 1 revealed a binuclear octahedrally coordinated cobalt(II) complex formed by bridging a PDCA(2-) between metal centers. In the mononuclear complex 2, the copper atom has an octahedral geometry with CuN2O4 environment formed by one DEA and one PDCA(2-) ligands in mer form. The ability of the H(2)PDCA and DEA ligands along with complexes 1 and 2 to interact with ten selected biomacromolecules (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS, Top II and B-DNA) were investigated by docking studies. The results showed that the studied compounds can bind to DNA and proteins.
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收藏
页码：1155 / 1163
页数：9
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共 61 条
  • [31] Vicinal amino alcohols as organocatalysts in asymmetric cross-aldol reaction of ketones:: Application in the synthesis of convolutamydine a
    Malkov, Andrei V.
    Kabeshov, Mikhail A.
    Bella, Marco
    Kysilka, Ondrej
    Malyshev, Denis A.
    Pluhackova, Kristyna
    Kocovsky, Pavel
    [J]. ORGANIC LETTERS, 2007, 9 (26) : 5473 - 5476
  • [32] Docking studies to evaluate the biological activities of the Co(II) and Ni(II) complexes containing the triazine unit: supported by structural, spectral, and theoretical studies
    Marandi, Farzin
    Moeini, Keyvan
    Arkak, Akbar
    Mardani, Zahra
    Krautscheid, Harald
    [J]. JOURNAL OF COORDINATION CHEMISTRY, 2018, 71 (23) : 3893 - 3911
  • [33] Treatment of cadmium(II) and zinc(II) with N2-donor linkages in presence of β-diketone ligand; supported by structural, spectral, theoretical and docking studies
    Marandi, Farzin
    Moeini, Keyvan
    Alizadeh, Fereshteh
    Mardani, Zahra
    Quah, Ching Kheng
    Loh, Wan-Sin
    Woollins, J. Derek
    [J]. INORGANICA CHIMICA ACTA, 2018, 482 : 717 - 725
  • [34] Structural, spectral and docking studies of a coordination polymer of zinc(II) formed by a pyridine-derived linker
    Marandi, Farzin
    Moeini, Keyvan
    Alizadeh, Fereshteh
    Mardani, Zahra
    Quah, Ching Kheng
    Loh, Wan-Sin
    [J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2018, 73 (06): : 369 - 375
  • [35] Structural, spectral and theoretical aspects in the coordination of a triazine-based ligand toward lead(II) with a holodirected environment
    Marandi, Farzin
    Moeini, Keyvan
    Mostafazadeh, Bahman
    Krautscheid, Harald
    [J]. POLYHEDRON, 2017, 133 : 146 - 154
  • [36] Structural and spectral study of coordination of 4,4′-dimethoxy-2,2′-bipyridine toward Zn(II) and Cd(II) containing thiocyanato or azido ligands
    Marandi, Farzin
    Moeini, Keyvan
    Rudbari, Hadi Amiri
    [J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2016, 71 (09): : 959 - 965
  • [37] A novel ligand transfer reaction: Transferring an N3-donor amine ligand from Ni(II) to Cu(II)-structural, spectral, theoretical, and docking studies
    Mardani, Zahra
    Dorjani, Sima
    Moeini, Keyvan
    Darroudi, Majid
    Carpenter-Warren, Cameron
    Slawin, Alexandra M. Z.
    Woollins, J. Derek
    [J]. JOURNAL OF CHEMICAL RESEARCH, 2019, 43 (9-10) : 330 - 339
  • [38] Structural conversion of an oxazolidine ligand upon treatment with copper(I) and (II) halides; structural, spectral, theoretical and docking studies
    Mardani, Zahra
    Golsanamlou, Vali
    Jabbarzadeh, Zahra
    Moeini, Keyvan
    Khodavandegar, Saba
    Carpenter-Warren, Cameron
    Slawin, Alexandra M. Z.
    Woollins, J. Derek
    [J]. JOURNAL OF COORDINATION CHEMISTRY, 2018, 71 (24) : 4109 - 4131
  • [39] Anticancer activities of a β-amino alcohol ligand and nanoparticles of its copper(II) and zinc(II) complexes evaluated by experimental and theoretical methods
    Mardani, Zahra
    Kazemshoar-Duzduzani, Reza
    Moeini, Keyvan
    Hajabbas-Farshchi, Alireza
    Carpenter-Warren, Cameron
    Slawin, Alexandra M. Z.
    Woollins, J. Derek
    [J]. RSC ADVANCES, 2018, 8 (50): : 28810 - 28824
  • [40] Synthesis, characterization and antitumoral activity of new cobalt(II)complexes: Effect of the ligand isomerism on the biological activity of the complexes
    Morcelli, Samila R.
    Bull, Erika S.
    Terra, Wagner S.
    Moreira, Rafaela O.
    Borges, Franz V.
    Kanashiro, Milton M.
    Bortoluzzi, Adailton J.
    Maciel, Leide L. F.
    Almeida, Joao Carlos de A.
    Horn Junior, Adolfo
    Fernandes, Christiane
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2016, 161 : 73 - 82
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