Aberrant local striatal functional connectivity in attention-deficit/hyperactivity disorder

被引:21
作者
von Rhein, Daniel [1 ,2 ]
Oldehinkel, Marianne [1 ,2 ]
Beckmann, Christian F. [1 ,2 ,3 ]
Oosterlaan, Jaap [4 ]
Heslenfeld, Dirk [4 ]
Hartman, Catharina A. [5 ]
Hoekstra, Pieter J. [5 ]
Franke, Barbara [6 ,7 ]
Cools, Roshan [2 ,7 ]
Buitelaar, Jan K. [1 ,2 ,8 ]
Mennes, Maarten [2 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
[3] Univ Oxford, Ctr Funct MRI Brain FMRIB, Oxford, England
[4] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands
[5] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
[6] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands
[7] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen, Netherlands
[8] Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands
基金
欧洲研究理事会;
关键词
Resting-state fMRI; functional connectivity; attention-deficit/hyperactivity disorder; cortico-striatal networks; striatum; putamen; ARTIFACT REMOVAL; ICA-AROMA; RELIABILITY; CHILDREN; MOTION; VALIDITY; ROBUST; HETEROGENEITY; ACCURATE; ADULTS;
D O I
10.1111/jcpp.12529
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Background: Task-based and resting-state functional Magnetic Resonance Imaging (fMRI) studies report attention-deficit/hyperactivity disorder (ADHD)-related alterations in brain regions implicated in cortico-striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico-striatal functional architecture, or whether ADHD-related alterations are limited to local, intrastriatal functional connections. Methods: We included a cohort of adolescents with ADHD (N = 181) and healthy controls (N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico-striatal functional architecture we computed whole-brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results: Diagnostic status did not influence global cortico-striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen (p = .0003; ADHD: z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions: Our results do not support hypotheses that ADHD is associated with alterations in cortico-striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD.
引用
收藏
页码:697 / 705
页数:9
相关论文
共 45 条
  • [1] Striatal dopamine and the interface between motivation and cognition
    Aarts, Esther
    van Holstein, Mieke
    Cools, Roshan
    [J]. FRONTIERS IN PSYCHOLOGY, 2011, 2
  • [2] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX
    ALEXANDER, GE
    DELONG, MR
    STRICK, PL
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 : 357 - 381
  • [3] Movement Initiation-Locked Activity of the Anterior Putamen Predicts Future Movement Instability in Periodic Bimanual Movement
    Aramaki, Yu
    Haruno, Masahiko
    Osu, Rieko
    Sadato, Norihiro
    [J]. JOURNAL OF NEUROSCIENCE, 2011, 31 (27) : 9819 - 9823
  • [4] Abnormal resting-state functional connectivity patterns of the putamen in medication-naive children with attention deficit hyperactivity disorder
    Cao, Xiaohua
    Cao, Qingjiu
    Long, Xiangyu
    Sun, Li
    Sui, Manqiu
    Zhu, Chaozhe
    Zuo, Xinian
    Zang, Yufeng
    Wang, Yufeng
    [J]. BRAIN RESEARCH, 2009, 1303 : 195 - 206
  • [5] Conners C. K., 1999, CONNERSADULT ADHD RA
  • [6] The revised Conners' Parent Rating Scale (CPRS-R): Factor structure, reliability, and criterion validity
    Conners, CK
    Sitarenios, G
    Parker, JDA
    Epstein, JN
    [J]. JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 1998, 26 (04) : 257 - 268
  • [7] Revision and restandardization of the Conners Teacher Rating Scale (CTRS-R): Factor structure, reliability, and criterion validity
    Conners, CK
    Sitarenios, G
    Parker, JDA
    Epstein, JN
    [J]. JOURNAL OF ABNORMAL CHILD PSYCHOLOGY, 1998, 26 (04) : 279 - 291
  • [8] Toward Systems Neuroscience of ADHD: A Meta-Analysis of 55 fMRI Studies
    Cortese, Samuele
    Kelly, Clare
    Chabernaud, Camille
    Proal, Erika
    Di Martino, Adriana
    Milham, Michael P.
    Castellanos, F. Xavier
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2012, 169 (10) : 1038 - 1055
  • [9] A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention
    Cubillo, Ana
    Halari, Rozmin
    Smith, Anna
    Taylor, Eric
    Rubia, Katya
    [J]. CORTEX, 2012, 48 (02) : 194 - 215
  • [10] Functional Connectivity of Human Striatum: A Resting State fMRI Study
    Di Martino, A.
    Scheres, A.
    Margulies, D. S.
    Kelly, A. M. C.
    Uddin, L. Q.
    Shehzad, Z.
    Biswal, B.
    Walters, J. R.
    Castellanos, F. X.
    Milham, M. P.
    [J]. CEREBRAL CORTEX, 2008, 18 (12) : 2735 - 2747