Electrical Synapses Control Hippocampal Contributions to Fear Learning and Memory

被引：88

作者：

Bissiere, Stephanie ^{[1
]}

Zelikowsky, Moriel ^{[1
]}

Ponnusamy, Ravikumar ^{[1
]}

Jacobs, Nathan S. ^{[1
]}

Blair, Hugh T. ^{[1
]}

Fanselow, Michael S. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

来源：

SCIENCE | 2011年 / 331卷 / 6013期

关键词：

BASOLATERAL AMYGDALA; MAMMALIAN BRAIN; THETA-RHYTHM; OSCILLATIONS; CONNEXIN36; SYNCHRONIZATION; INTERNEURONS; IMPAIRMENT; MODULATION; PLASTICITY;

D O I：

10.1126/science.1193785

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of electrical synapses in synchronizing neuronal assemblies in the adult mammalian brain is well documented. However, their role in learning and memory processes remains unclear. By combining Pavlovian fear conditioning, activity-dependent immediate early gene expression, and in vivo electrophysiology, we discovered that blocking neuronal gap junctions within the dorsal hippocampus impaired context-dependent fear learning, memory, and extinction. Theta rhythms in freely moving rats were also disrupted. Our results show that gap junction-mediated neuronal transmission is a prominent feature underlying emotional memories.

引用

页码：87 / 91

页数：5

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