Human induced pluripotent stem cell-derived kidney organoids toward clinical implementations

被引：9

作者：

Garreta, Elena ^{[1
,2
]}

Nauryzgaliyeva, Zarina ^{[3
]}

Montserrat, Nuria ^{[1
,4
,5
]}

机构：

[1] Barcelona Inst Sci & Technol BIST, Inst Bioengn Catalonia IBEC, Pluripotency Organ Regenerat, Barcelona 08028, Spain

[2] Univ Barcelona, Barcelona 08028, Spain

[3] Barcelona Inst Sci & Technol BIST, Inst Bioengn Catalonia IBEC, Barcelona 08028, Spain

[4] Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Barcelona, Spain

[5] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain

来源：

CURRENT OPINION IN BIOMEDICAL ENGINEERING | 2021年 / 20卷

基金：

欧盟地平线“2020”;

关键词：

Human pluripotent stem cells; Kidney organoids; Disease modeling; CRISPR/Cas9 gene editing; Kidney regeneration; Bioengineering; CONVERTING ENZYME-II; EXTRACELLULAR-MATRIX; GENERATION; DISEASE; MODEL; TRANSPLANTATION; SCAFFOLD; REVEALS; MOUSE;

D O I：

10.1016/j.cobme.2021.100346

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The generation of kidney organoids from human pluripotent stem cells (hPSCs) has represented a relevant scientific achievement in the organoid field. Importantly, hPSC-derived kidney organoids contain multiple nephron-like structures that exhibit some renal functional characteristics and have the capacity to respond to nephrotoxic agents. In this review, we first discuss how bioengineering approaches can help overcome current kidney organoid challenges. Next, we focus on recent works exploiting kidney organoids for drug screening and disease modeling applications. Finally, we provide a state of the art on current research toward the potential application of kidney organoids and renal cells derived from hPSCs for future renal replacement therapies.

引用

页数：13

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