Juniperus chinensis and the functional compounds, cedrol and widdrol, ameliorate α-melanocyte stimulating hormone-induced melanin formation in B16F10 cells

被引：10
|
作者：
Jin, Kyong-Suk [1 ]
Lee, Ji Young [1 ]
Hyun, Sook Kyung [1 ,2 ]
Kim, Byung Woo [1 ,3 ]
Kwon, Hyun Ju [1 ,3 ]
机构：
[1] Dong Eui Univ, Blue Bio Ind Reg Innovat Ctr, Pusan 614714, South Korea
[2] Dong Eui Univ, Dept Food & Nutr, Coll Nat Sci & Human Ecol, Pusan 614714, South Korea
[3] Dong Eui Univ, Dept Life Sci & Biotechnol, Coll Nat Sci & Human Ecol, Pusan 614714, South Korea
来源：
FOOD SCIENCE AND BIOTECHNOLOGY | 2015年 / 24卷 / 02期
关键词：
Juniperus chinensis; anti-oxidative activity; anti-melanogenic activity; functional compound; ACTIVATED PROTEIN-KINASE; IN-VITRO; ESSENTIAL OIL; DNA-DAMAGE; MELANOGENESIS; TYROSINASE; CONSTITUENTS; INHIBITION; MECHANISMS; HEARTWOOD;
D O I：
10.1007/s10068-015-0080-5
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Anti-melanogenic activities of Juniperus chinensis methanol extracts (JCM) and isolation of functional compounds were investigated. JCM possessed potent anti-oxidative and tyrosinase inhibitory activities. alpha-Melanocyte stimulating hormone (alpha-MSH)-induced melanogenesis and tyrosinase activity were inhibited by JCM in B16F10 cells. JCM also possessed potent scavenging activities against hydrogen peroxide induced reactive oxygen species (ROS). The dichloromethane (CH2Cl2) solvent fraction only exhibited an anti-melanogenic activity with a potent ROS scavenging potential. The main compounds in the CH2Cl2 fraction were cedrol (CR) and widdrol (WR), which inhibited melanogenesis both individually and synergistically. As the results, J. chinensis possesses potent anti-oxidative and anti-melanogenic activities due to active compounds, CR and WR. J. chinensis, CR, and WR provide promising new strategies for anti-oxidative and depigmenting resources.
引用
收藏
页码：611 / 618
页数：8
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