New strategy for the total synthesis of macrosphelides A and B based on ring-closing metathesis

被引：47

作者：

Matsuya, Y ^{[1
]}

Kawaguchi, T ^{[1
]}

Nemoto, H ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 16期

关键词：

D O I：

10.1021/ol0350689

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described. The substrate of the RCM could be synthesized from readily available chiral materials, methyl (S)-(+)-3-hydroxybutyrate and methyl (S)-(-)-lactate, with a high efficiency. The RCM proceeded in the presence of Grubbs' Ru-complex, providing a new effective synthetic route to these natural products.

引用

页码：2939 / 2941

页数：3

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