CELL AND MOLECULAR BIOLOGY OF MICROTUBULE PLUS END TRACKING PROTEINS: END BINDING PROTEINS AND THEIR PARTNERS

被引：53

作者：

Gouveia, Susana Montenegro ^{[1
]}

Akhmanova, Anna ^{[1
]}

机构：

[1] Erasmus MC, Dept Cell Biol, Rotterdam, Netherlands

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 285 | 2010年 / 285卷

关键词：

Microtubule; EB1; CLIP; 170; APC; Spectraplakin; STIM1; Kinesin; Dynein; ADENOMATOUS-POLYPOSIS-COLI; APC TUMOR-SUPPRESSOR; CYTOPLASMIC LINKER PROTEIN-170; SLOWLY HYDROLYZABLE ANALOG; SPINDLE POLE ORGANIZATION; LISSENCEPHALY GENE LIS1; AMINO-ACID-SEQUENCE; LINKING FACTOR MACF; MITOTIC SPINDLE; DYNAMIC INSTABILITY;

D O I：

10.1016/S1937-6448(10)85001-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microtubule plus end is a crucial site for the regulation of microtubule dynamics and microtubule association with different cellular organelles and macromolecular complexes Several evolutionarily conserved groups of proteins form comet like accumulations at the growing microtubule plus ends These proteins belong to functionally diverse and structurally unrelated families they include motors, nonmotor proteins, microtubule polymerases, and depolymerases as well as regulatory and adaptor proteins Here, we provide an overview of microtubule plus end binding proteins, describe what is known about the mechanisms of their association with growing microtubule tips, and discuss their functional properties in relation to microtubule plus end accumulation

引用

页码：1 / 74

页数：74

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