Conservation of Resistance-Nodulation-Cell Division Efflux Pump-Mediated Antibiotic Resistance in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Species

被引：7
作者：
Somprasong, Nawarat [1 ]
Yi, Jinhee [1 ]
Hall, Carina M. [1 ]
Webb, Jessica R. [2 ]
Sahl, Jason W. [1 ]
Wagner, David M. [1 ]
Keim, Paul [1 ]
Currie, Bart J. [2 ,3 ,4 ]
Schweizer, Herbert P. [1 ]
机构：
[1] No Arizona Univ, Pathogen & Microbiome Inst, Flagstaff, AZ 86011 USA
[2] Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia
[3] Royal Darwin Hosp, Dept Infect Dis, Darwin, NT, Australia
[4] Royal Darwin Hosp, Northern Terr Med Program, Darwin, NT, Australia
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 09期
关键词：
Burkholderia; multidrug resistance; RND efflux pumps; BPEAB-OPRB; AMINOGLYCOSIDES;
D O I：
10.1128/AAC.00920-21
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkhoideria. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.
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页数：7
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