Predictive biomarkers of response to immune checkpoint inhibitors in melanoma

被引：22

作者：

Nebhan, Caroline A. ^{[1
,2
]}

Johnson, Douglas B. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2020年 / 20卷 / 02期

关键词：

Melanoma; immunotherapy; PD-1; biomarkers; CTLA-4; METASTATIC MELANOMA; CLINICAL-RESPONSE; CTLA-4; BLOCKADE; PD-1; T-CELLS; IPILIMUMAB; NIVOLUMAB; ANTI-PD-1; COMBINATION; LANDSCAPE;

D O I：

10.1080/14737140.2020.1724539

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Advanced melanoma has recently been transformed by the advent of immune checkpoint inhibitors. These agents have altered the prognosis of this disease from a median survival of Areas covered: In this review, we discuss the clinical and investigational utility of predictive biomarkers of immune checkpoint inhibitor treatment in melanoma. Topics include tumor-intrinsic biomarkers, tumor microenvironment biomarkers, and host characteristic biomarkers. We also discuss biomarkers of immune-related adverse events and how biomarkers may be used to personalize the selection of immune checkpoint inhibition in patients. Expert opinion: The decisions confronting oncologists when choosing treatment are increasing in complexity. Biomarkers may aid in these treatment decisions and are growing in importance.

引用

页码：137 / 145

页数：9

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