Predictive biomarkers of response to immune checkpoint inhibitors in melanoma

被引：19

作者：

Nebhan, Caroline A. ^{[1
,2
]}

Johnson, Douglas B. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2020年 / 20卷 / 02期

关键词：

Melanoma; immunotherapy; PD-1; biomarkers; CTLA-4; METASTATIC MELANOMA; CLINICAL-RESPONSE; CTLA-4; BLOCKADE; PD-1; T-CELLS; IPILIMUMAB; NIVOLUMAB; ANTI-PD-1; COMBINATION; LANDSCAPE;

D O I：

10.1080/14737140.2020.1724539

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: Advanced melanoma has recently been transformed by the advent of immune checkpoint inhibitors. These agents have altered the prognosis of this disease from a median survival of Areas covered: In this review, we discuss the clinical and investigational utility of predictive biomarkers of immune checkpoint inhibitor treatment in melanoma. Topics include tumor-intrinsic biomarkers, tumor microenvironment biomarkers, and host characteristic biomarkers. We also discuss biomarkers of immune-related adverse events and how biomarkers may be used to personalize the selection of immune checkpoint inhibition in patients. Expert opinion: The decisions confronting oncologists when choosing treatment are increasing in complexity. Biomarkers may aid in these treatment decisions and are growing in importance.

引用

页码：137 / 145

页数：9

共 72 条

[1] High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
Atkins, MB
Lotze, MT
Dutcher, JP
Fisher, RI
Weiss, G
Margolin, K
Abrams, J
Sznol, M
Parkinson, D
Hawkins, M
Paradise, C
Kunkel, L
Rosenberg, SA
[J]. JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (07) : 2105 - 2116
[2] Combination of Alphavirus Replicon Particle-Based Vaccination with Immunomodulatory Antibodies: Therapeutic Activity in the B16 Melanoma Mouse Model and Immune Correlates
Avogadri, Francesca
Zappasodi, Roberta
Yang, Arvin
Budhu, Sadna
Malandro, Nicole
Hirschhorn-Cymerman, Daniel
Tiwari, Shakuntala
Maughan, Maureen F.
Olmsted, Robert
Wolchok, Jedd D.
Merghoub, Taha
[J]. CANCER IMMUNOLOGY RESEARCH, 2014, 2 (05) : 448 - 458
[3] IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade
Ayers, Mark
Lunceford, Jared
Nebozhyn, Michael
Murphy, Erin
Loboda, Andrey
Kaufman, David R.
Albright, Andrew
Cheng, Jonathan D.
Kang, S. Peter
Shankaran, Veena
Piha-Paul, Sarina A.
Yearley, Jennifer
Seiwert, Tanguy Y.
Ribas, Antoni
McClanahan, Terrill K.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (08) : 2930 - 2940
[4] Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination
Boutros, Celine
Tarhini, Ahmad
Routier, Emilie
Lambotte, Olivier
Ladurie, Francois Leroy
Carbonnel, Franck
Izzeddine, Hassane
Marabelle, Aurelien
Champiat, Stephane
Berdelou, Armandine
Lanoy, Emilie
Texier, Matthieu
Libenciuc, Cristina
Eggermont, Alexander M. M.
Soria, Jean-Charles
Mateus, Christine
Robert, Caroline
[J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2016, 13 (08) : 473 - 486
[5] MYC regulates the antitumor immune response through CD47 and PD-L1
Casey, Stephanie C.
Tong, Ling
Li, Yulin
Do, Rachel
Walz, Susanne
Fitzgerald, Kelly N.
Gouw, Arvin M.
Baylot, Virginie
Guetgemann, Ines
Eilers, Martin
Felsher, Dean W.
[J]. SCIENCE, 2016, 352 (6282) : 227 - 231
[6] Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
Chalmers, Zachary R.
Connelly, Caitlin F.
Fabrizio, David
Gay, Laurie
Ali, Siraj M.
Ennis, Riley
Schrock, Alexa
Campbell, Brittany
Shlien, Adam
Chmielecki, Juliann
Huang, Franklin
He, Yuting
Sun, James
Tabori, Uri
Kennedy, Mark
Lieber, Daniel S.
Roels, Steven
White, Jared
Otto, Geoffrey A.
Ross, Jeffrey S.
Garraway, Levi
Miller, Vincent A.
Stephens, Phillip J.
Frampton, Garrett M.
[J]. GENOME MEDICINE, 2017, 9
[7] Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade
Chen, Pei-Ling
Roh, Whijae
Reuben, Alexandre
Cooper, Zachary A.
Spencer, Christine N.
Prieto, Peter A.
Miller, John P.
Bassett, Roland L.
Gopalakrishnan, Vancheswaran
Wani, Khalida
De Macedo, Mariana Petaccia
Austin-Breneman, Jacob L.
Jiang, Hong
Chang, Qing
Reddy, Sangeetha M.
Chen, Wei-Shen
Tetzlaff, Michael T.
Broaddus, Russell J.
Davies, Michael A.
Gershenwald, Jeffrey E.
Haydu, Lauren
Lazar, Alexander J.
Patel, Sapna P.
Hwu, Patrick
Hwu, Wen-Jen
Diab, Adi
Glitza, Isabella C.
Woodman, Scott E.
Vence, Luis M.
Wistuba, Ignacio I.
Amaria, Rodabe N.
Kwong, Lawrence N.
Prieto, Victor
Davis, R. Eric
Ma, Wencai
Overwijk, Willem W.
Sharpe, Arlene H.
Hu, Jianhua
Futreal, P. Andrew
Blando, Jorge
Sharma, Padmanee
Allison, James P.
Chin, Lynda
Wargo, Jennifer A.
[J]. CANCER DISCOVERY, 2016, 6 (08) : 827 - 837
[8] Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
Chowell, Diego
Morris, Luc G. T.
Grigg, Claud M.
Weber, Jeffrey K.
Samstein, Robert M.
Makarov, Vladimir
Kuo, Fengshen
Kendall, Sviatoslav M.
Requena, David
Riaz, Nadeem
Greenbaum, Benjamin
Carroll, James
Garon, Edward
Hyman, David M.
Zehir, Ahmet
Solit, David
Berger, Michael
Zhou, Ruhong
Rizvi, Naiyer A.
Chan, Timothy A.
[J]. SCIENCE, 2018, 359 (6375) : 582 - +
[9] Cutaneous Melanoma Version 2.2019
Coit, Daniel G.
Thompson, John A.
Albertini, Mark R.
Barker, Christopher
Carson, William E., III
Contreras, Carlo
Daniels, Gregory A.
DiMaio, Dominick
Fields, Ryan C.
Fleming, Martin D.
Freeman, Morganna
Galan, Anjela
Gastman, Brian
Guild, Valerie
Johnson, Douglas
Joseph, Richard W.
Lange, Julie R.
Nath, Sameer
Olszanski, Anthony J.
Ott, Patrick
Gupta, Aparna Priyanath
Ross, Merrick, I
Salama, April K.
Skitzki, Joseph
Sosman, Jeffrey
Swetter, Susan M.
Tanabe, Kenneth K.
Wuthrick, Evan
McMillian, Nicole R.
Engh, Anita M.
[J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2019, 17 (04): : 367 - 402
[10] Early B cell changes predict autoimmunity following combination immune checkpoint blockade
Das, Rituparna
Bar, Noffar
Ferreira, Michelle
Newman, Aaron M.
Zhang, Lin
Bailur, Jithendra Kini
Bacchiocchi, Antonella
Kluger, Harriet
Wei, Wei
Halaban, Ruth
Sznol, Mario
Dhodapkar, Madhav V.
Dhodapkar, Kavita M.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (02) : 715 - 720

← 1 2 3 4 5 6 7 8 →