Convenient Synthesis of Quinolines from α-2-Nitroaryl Alcohols and Alcohols via a Ruthenium-catalyzed Hydrogen Transfer Strategy

被引：51

作者：

Xie, Feng ^{[1
,2
]}

Zhang, Min ^{[1
]}

Chen, Mengmeng ^{[2
]}

Lv, Wan ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510641, Guangdong, Peoples R China

[2] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China

来源：

CHEMCATCHEM | 2015年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

alcohols; annulation; homogeneous catalysis; hydrogen transfer; quinolines; ruthenium; H BOND FUNCTIONALIZATION; SECONDARY ALCOHOLS; BORROWING HYDROGEN; DEHYDROGENATIVE SYNTHESIS; SUBSTITUTED QUINOLINES; IRIDIUM CATALYSTS; AMINE FORMATION; ALKYLATION; DIAMINES; MILD;

D O I：

10.1002/cctc.201402832

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new and straightforward method for convenient synthesis of quinolines via a ruthenium-catalyzed hydrogen-transfer strategy has been demonstrated. By employing a commercially available ruthenium catalyst system, different alpha-2-nitroaryl alcohols were efficiently converted in combination with a variety of alcohols into various substituted products in reasonable to good yields upon isolation. The synthetic protocol is operationally simple with a broad substrate scope, and there is no need for the use of specialized reducing agents, making it a practical approach for versatile preparation of various quinoline derivatives.

引用

页码：349 / 353

页数：5

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