DESIGN AND DEVELOPMENT OF BENDAMUSTINE LOADED CHITOSAN NANOPARTICLE IN-VITRO CYTOTOXICITY

被引：2

作者：

Sankar, C. ^{[1
]}

Muthukumar, S. ^{[1
]}

Arulkumaran, G. ^{[1
]}

Shalini, S. ^{[2
]}

Sundaraganapathy, R. ^{[3
]}

Vanitha, N. ^{[1
]}

机构：

[1] KMCH Coll Pharm, Dept Pharmaceut, Coimbatore 641048, Tamil Nadu, India

[2] KMCH Coll Pharm, Dept Pharm Practice, Coimbatore 641048, Tamil Nadu, India

[3] Karpagam Acad Higher Educ, Fac Pharm, Coimbatore 641021, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2020年 / 11卷 / 02期

关键词：

Nanoparticles; Passive targeting; Ionotropic gelation; Cytotoxicity; HeLa cell lines; PROLIFERATION;

D O I：

10.13040/IJPSR.0975-8232.11(2).755-64

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanoparticles represent one of the alternatives in the treatment of cancer chemotherapy. In the present study, the prime objective was to formulate anti-cancer drug, bendamustine into polymeric chitosan nanocarrier system for its sustained release and passive targeting mechanism. Based on particle size, zeta potential and polydispersity index, F3 was selected as the optimized formulation. The SEM images revealed nanostructure with linear/rod shape enabling better internalization. The X-ray powder diffraction analysis clearly indicates reduction in crystallinity of bendamustine in nanoparticles. The nanoparticle formulation showed good results in terms of assayed drug content and encapsulation efficiency. The in-vitro permeation studies using egg membrane revealed that F3 formulation showed a sustained drug release for 28 h with an initial burst release within 1 h.

引用

页码：755 / 764

页数：10

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