OXA-35 is an OXA-10-related β-lactamase from Pseudomonas aeruginosa

被引：30

作者：

Aubert, D

Poirel, L

Ben Ali, A

Goldstein, FW

Nordmann, P ^{[1
]}

机构：

[1] Assistance Publ Hop Paris, Hop Bicetre, Fac Med Paris Sud, Serv Bacteriol Virol, F-94275 Le Kremlin Bicetre, France

[2] Hop St Joseph, Bacteriol Lab, F-75014 Paris, France

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2001年 / 48卷 / 05期

关键词：

D O I：

10.1093/jac/48.5.717

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pseudomonas aeruginosa clinical isolate PA35 is resistant to amino- and ureido-penicillins, has intermediate susceptibility to cefsulodin, cefepime and aztreonam, and is susceptible to imipenem and ceftazidime. Cloning and sequencing revealed a new,6-lactamase variant, OXA-35, sharing 96% amino acid identity with OXA-10. OXA-35 displays a restricted-substrate hydrolysis profile with improved hydrolysis of amoxicillin and cloxacillin compared with OXA-10. OXA-35 differs from derivatives OXA-19 and OXA-28 by one amino acid substitution and may be a progenitor of these OXA-13-like extended-spectrum,beta -lactamases.

引用

页码：717 / 721

页数：5

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