Calcium signalling remodelling and disease

被引:282
作者
Berridge, Michael J. [1 ]
机构
[1] Babraham Inst, Cambridge CB22 3AT, England
基金
英国生物技术与生命科学研究理事会;
关键词
Alzheimer's disease; bipolar disorder; calcium; heart; inositol; schizophrenia; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; ALZHEIMERS-DISEASE; UP-REGULATION; CA2+; RELEASE; DYSREGULATION; OSCILLATIONS; HYPERTROPHY; CONTRACTION; ARRHYTHMIAS;
D O I
10.1042/BST20110766
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A wide range of Ca2+ signalling systems deliver the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. Release of Ca2+ by InsP(3) (inositol 1,4,5-trisphosphate) plays a central role in many of these signalling systems. Ongoing transcriptional processes maintain the integrity and stability of these cell-specific signalling systems. However, these homoeostatic systems are highly plastic and can undergo a process of phenotypic remodelling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease.
引用
收藏
页码:297 / 309
页数:13
相关论文
共 50 条
[31]   Calcium signalling in diabetes [J].
Guerrero-Hernandez, Agustin ;
Verkhratsky, Alexei .
CELL CALCIUM, 2014, 56 (05) :297-301
[32]   Calcium signalling - an overview [J].
Bootman, MD ;
Collins, TJ ;
Peppiatt, CM ;
Prothero, LS ;
MacKenzie, L ;
De Smet, P ;
Travers, M ;
Tovey, SC ;
Seo, JT ;
Berridge, MJ ;
Ciccolini, F ;
Lipp, P .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2001, 12 (01) :3-10
[33]   Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling [J].
Clavere, Nicolas G. ;
Alqallaf, Ali ;
Rostron, Kerry A. ;
Parnell, Andrew ;
Mitchell, Robert ;
Patel, Ketan ;
Boateng, Samuel Y. .
DISEASE MODELS & MECHANISMS, 2022, 15 (05)
[34]   CALCIUM SIGNALLING MODULATES VSMC RESPONSE TO MATRIX STIFFNESS IN AGEING AND DISEASE [J].
Wostear, Finn ;
Johnson, Robert. T. ;
Warren, Derek. T. .
HEART, 2023, 109 :A279-A279
[35]   3D mathematical modeling of calcium signaling in Alzheimer's disease [J].
Dave, Devanshi D. ;
Jha, Brajesh Kumar .
NETWORK MODELING AND ANALYSIS IN HEALTH INFORMATICS AND BIOINFORMATICS, 2020, 9 (01)
[36]   Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond [J].
Webber, Elise K. ;
Fivaz, Marc ;
Stutzmann, Grace E. ;
Griffioen, Gerard .
ALZHEIMERS & DEMENTIA, 2023, 19 (08) :3701-3717
[37]   The dysregulation of intracellular calcium in Alzheimer disease [J].
Supnet, Charlene ;
Bezprozvanny, Ilya .
CELL CALCIUM, 2010, 47 (02) :183-189
[38]   Dysregulation of calcium in Alzheimer's disease [J].
Brzyska, M ;
Elbaum, D .
ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 2003, 63 (03) :171-183
[39]   Calcium signalling: A common target in neurological disorders and neurogenesis [J].
Glaser, Talita ;
Arnaud Sampaio, Vanessa Fernandes ;
Lameu, Claudiana ;
Ulrich, Henning .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2019, 95 :25-33
[40]   Introduction to a Virtual Special Issue on calcium signalling in plants [J].
Brownlee, Colin ;
Hetherington, Alistair .
NEW PHYTOLOGIST, 2011, 192 (04) :786-789