Synthesis of spiro-bisperoxyketals

被引：77
作者：
Ghorai, Prasanta [1 ]
Dussault, Patrick H. [1 ]
Hu, Chunhua [2 ]
机构：
[1] Univ Nebraska, Dept Chem, Lincoln, NE 68588 USA
[2] Univ Nebraska, Nebraska Ctr Mat & Nanosci, Lincoln, NE 68588 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 12期
关键词：
D O I：
10.1021/ol800657m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Syntheses of spirocyclic bis-1,2-dioxolanes, bis-1,2-dioxanes, and bis-1,2-dioxepanes are achieved through intramolecular ketalizations of hydroperoxy ketones or intramolecular alkylations of gern-dihydroperoxides. The spiroperoxides have excellent thermal and chemical stability, and several display promising activity against A falciparum.
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页码：2401 / 2404
页数：4
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