Fluorescence Lifetime Techniques in Medical Applications

被引：192

作者：

Marcu, Laura ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2012年 / 40卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Time-resolved fluorescence spectroscopy and imaging; Medical applications of optical technologies; Tissue diagnosis in vivo; DIFFUSE-REFLECTANCE SPECTROSCOPY; TIME-RESOLVED AUTOFLUORESCENCE; MULTIPHOTON LASER TOMOGRAPHY; IN-VIVO DIAGNOSIS; OPTICAL SPECTROSCOPY; ATHEROSCLEROTIC PLAQUE; NONINVASIVE EVALUATION; TRACHEOBRONCHIAL TREE; EXCITED FLUORESCENCE; VULNERABLE PLAQUE;

D O I：

10.1007/s10439-011-0495-y

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This article presents an overview of time-resolved (lifetime) fluorescence techniques used in biomedical diagnostics. In particular, we review the development of time-resolved fluorescence spectroscopy (TRFS) and fluorescence lifetime imaging (FLIM) instrumentation and associated methodologies which allow in vivo characterization and diagnosis of biological tissues. Emphasis is placed on the translational research potential of these techniques and on evaluating whether intrinsic fluorescence signals provide useful contrast for the diagnosis of human diseases including cancer (gastrointestinal tract, lung, head and neck, and brain), skin and eye diseases, and atherosclerotic cardiovascular disease.

引用

页码：304 / 331

页数：28

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