Uterine tumors:: Pathophysiologic imaging with 16α-[18F]fluoro-17β-estradiol and 18F fluorodeoxyglucose PET-initial experience

被引：70

作者：

Tsujikawa, Tetsuya ^{[1
]}

Yoshida, Yoshio ^{[2
]}

Mori, Tetsuya ^{[1
]}

Kurokawa, Tetsuji ^{[2
]}

Fujibayashi, Yasuhisa ^{[1
]}

Kotsuji, Fumikazu ^{[2
]}

Okazawa, Hidehiko ^{[1
]}

机构：

[1] Univ Fukui, Fac Med Sci, Biomed Imaging Res Ctr, Fukui 9101193, Japan

[2] Univ Fukui, Fac Med Sci, Dept Gynecol, Fukui 9101193, Japan

来源：

RADIOLOGY | 2008年 / 248卷 / 02期

关键词：

D O I：

10.1148/radiol.2482071379

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To clarify prospectively the relationship between estrogen receptor (ER) expression and glucose metabolism by using 16 alpha-[F-18] fluoro-17 beta-estradiol (FES) and fluorine 18 (F-18) fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with benign and malignant uterine tumors. Materials and Methods: The institutional review board approved this study, and informed consent was obtained from all subjects. FES and FDG PET studies were performed in 38 patients (mean age, 54.1 years +/- 14.0 [standard deviation]) with benign and malignant uterine tumors to compare differences in tracer accumulation. Regional values of tracer uptake were evaluated by using standardized uptake value (SUV), a normalized value corrected by using injection dose and body weight. Results: Patients with endometrial carcinoma showed significantly greater mean SUV for FDG (9.6 +/- 3.3) than for FES (3.8 +/- 1.8) (P < .005). Patients with endometrial hyperplasia showed significantly higher mean SUV for FES (7.0 +/- 2.9) than for FDG (1.7 +/- 0.3) (P < .05). Patients with leiomyoma showed significantly higher mean SUV for FES (4.2 +/- 2.4) than for FDG (2.2 +/- 1.1) (P < .005), and patients with sarcoma showed opposite tendencies for tracer accumulation. Tracer uptake in patients with endometrial carcinoma was significantly higher for FDG (P < .001) and significantly lower for FES (P < .05) when compared with values in patients with endometrial hyperplasia. On the other hand, patients with sarcoma showed a significantly higher uptake for FDG (P < .005) and a significantly lower uptake for FES (P < .05) compared with patients with leiomyoma. Conclusion: ER expression and glucose metabolism of uterine tumors measured by using PET showed opposite tendencies. PET studies with both FES and FDG could provide pathophysiologic information for the differential diagnosis of uterine tumors. (C) RSNA, 2008.

引用

页码：599 / 605

页数：7

共 30 条

[11] Expression of GLUT-1 glucose transfer, cellular proliferation activity and grade of tumor correlate with [F-18]-fluorodeoxyglucose uptake by positron emission tomography in epithelial tumors of the ovary [J].