Automated synthesis of [18F]gefitinib on a modular system

被引：17
|
作者：
Lappchen, Tilman [1 ]
Vlaming, Maria L. H. [2 ]
Custers, Erica [1 ]
Lub, Johan [1 ]
Sio, Charles F. [1 ]
DeGroot, Jeroen [2 ]
Steinbach, Oliver C. [1 ]
机构：
[1] Philips Res Europe, Dept Biomol Engn, NL-5656 AE Eindhoven, Netherlands
[2] TNO, NL-3704 HE Zeist, Netherlands
来源：
APPLIED RADIATION AND ISOTOPES | 2012年 / 70卷 / 01期
关键词：
F-18]gefitinib; Modular system; Automated synthesis; PET tracer; Imaging of drug transporters; GROWTH-FACTOR RECEPTOR; P-GLYCOPROTEIN; TUMORS; BRAIN;
D O I：
10.1016/j.apradiso.2011.09.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
In recent years, [F-18]gefitinib PET has successfully been employed for a number of applications ranging from oncology to in vivo studies of drug transporter proteins. We here report a reliable, automated procedure for routine synthesis of this radiotracer on an Eckert and Ziegler modular system. The 3-step radiosynthesis followed by preparative HPLC-purification provided [F-18]gefitinib in 17.2 +/- 3.3% (n=22) overall decay-corrected radiochemical yield with radiochemical purity > 99% in a total synthesis time of about 2.5 h. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：205 / 209
页数：5
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