Modeling hepatitis C virus infection using human induced pluripotent stem cells

被引：158

作者：

Schwartz, Robert E. ^{[2
,6
]}

Trehan, Kartik ^{[2
]}

Andrus, Linda ^{[1
]}

Sheahan, Timothy P. ^{[1
]}

Ploss, Alexander ^{[1
]}

Duncan, Stephen A. ^{[4
]}

Rice, Charles M. ^{[1
]}

Bhatia, Sangeeta N. ^{[2
,3
,5
,6
]}

机构：

[1] Rockefeller Univ, Ctr Study Hepatitis C, Lab Virol & Infect Dis, New York, NY 10065 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[4] Med Coll Wisconsin, Dept Cell Biol Neurobiol & Anat, Milwaukee, WI 53226 USA

[5] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[6] Brigham & Womens Hosp, Div Med, Boston, MA 02115 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 07期

基金：

美国国家卫生研究院;

关键词：

host variation in disease; infectious disease model; personalized medicine; hepatotrophic infection; viral hepatitis; REPLICATION; RECEPTOR; CULTURE;

D O I：

10.1073/pnas.1121400109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cells and thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis.

引用

页码：2544 / 2548

页数：5

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