Sexual Dysfunction Due to Psychotropic Medications

被引：46

作者：

Clayton, Anita H. ^{[1
]}

Alkis, Andrew R. ^{[1
]}

Parikh, Nishant B. ^{[1
]}

Votta, Jennifer G. ^{[1
]}

机构：

[1] Univ Virginia, Dept Psychiat & Neurobehav Sci, 1215 Lee St, Charlottesville, VA 22903 USA

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2016年 / 39卷 / 03期

关键词：

Sexual dysfunction; Antidepressant-induced sexual dysfunction; Antipsychotic-induced sexual dysfunction; Psychotropic-induced sexual dysfunction; Psychotropic adverse effects; MAJOR DEPRESSIVE DISORDER; SEROTONIN REUPTAKE INHIBITOR; PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; FLUOXETINE-INDUCED ANORGASMIA; SUSTAINED-RELEASE BUPROPION; INDUCED RETROGRADE EJACULATION; SERUM PROLACTIN CONCENTRATIONS; TREATED SCHIZOPHRENIC-PATIENTS; DOUBLE-BLIND TRIAL;

D O I：

10.1016/j.psc.2016.04.006

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Sexual functioning is important to assess in patients with psychiatric illness as both the condition and associated treatment may contribute to sexual dysfunction (SD). Antidepressant medications, mood stabilizers, antipsychotics, and antianxiety agents may be associated with SD related to drug mechanism of action. Sexual adverse effects may be related to genetic risk factors, impact on neurotransmitters and hormones, and psychological elements. Effective strategies to manage medication-induced sexual dysfunction are initial choice of a drug unlikely to cause SD, switching to a different medication, and adding an antidote to reverse SD. Appropriate interventions should be determined on a clinical case-by-case basis.

引用

页码：427 / +

页数：38

共 226 条

[1] Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications [J].

Abbing-Karahagopian, V. ;

Huerta, C. ;

Souverein, P. C. ;

de Abajo, F. ;

Leufkens, H. G. M. ;

Slattery, J. ;

Alvarez, Y. ;

Miret, M. ;

Gil, M. ;

Oliva, B. ;

Hesse, U. ;

Requena, G. ;

de Vries, F. ;

Rottenkolber, M. ;

Schmiedl, S. ;

Reynolds, R. ;

Schlienger, R. G. ;

de Groot, M. C. H. ;

Klungel, O. H. ;

van Staa, T. P. ;

van Dijk, L. ;

Egberts, A. C. G. ;

Gardarsdottir, H. ;

De Bruin, M. L. .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 70 (07) :849-857

[2] EFFECTS OF A NEW TYPE OF 5-HT RECEPTOR AGONIST ON MALE-RAT SEXUAL-BEHAVIOR [J].

AHLENIUS, S ;

LARSSON, K ;

SVENSSON, L ;

HJORTH, S ;

CARLSSON, A ;

LINDBERG, P ;

WIKSTROM, H ;

SANCHEZ, D ;

ARVIDSSON, LE ;

HACKSELL, U ;

NILSSON, JLG .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1981, 15 (05) :785-792

[3] Lithium and male sexual function in affective patients [J].

Aizenberg, D ;

Sigler, M ;

Zemishlany, Z ;

Weizman, A .

CLINICAL NEUROPHARMACOLOGY, 1996, 19 (06) :515-519

[4]

[Anonymous], 2013, Health, United States, 2012: With Special Feature on Emergency Care

[5]

[Anonymous], 2013, DEPRESS RES TREAT

[6] SUCCESSFUL TREATMENT OF FLUVOXAMINE-INDUCED ANORGASMIA BY CYPROHEPTADINE [J].

ARNOTT, S ;

NUTT, D .

BRITISH JOURNAL OF PSYCHIATRY, 1994, 164 :838-839

[7] Efficacy and tolerability of tricyclic antidepressants and SSRIs compared with placebo for treatment of depression in primary care: A meta-analysis [J].

Arroll, B ;

Macgillivray, S ;

Ogston, S ;

Reid, I ;

Sullivan, F ;

Williams, B ;

Crombie, I .

ANNALS OF FAMILY MEDICINE, 2005, 3 (05) :449-456

[8] Improvements in SSRI/SNRI-induced sexual dysfunction by switching to escitalopram [J].

Ashton, AK ;

Mahmood, A ;

Iqbal, F .

JOURNAL OF SEX & MARITAL THERAPY, 2005, 31 (03) :257-262

[9] Bupropion as an antidote for serotonin reuptake inhibitor-induced sexual dysfunction [J].

Ashton, AK ;

Rosen, RC .

JOURNAL OF CLINICAL PSYCHIATRY, 1998, 59 (03) :112-115

[10] Bidirectional Association Between Depression and Sexual Dysfunction: A Systematic Review and Meta-Analysis [J].

Atlantis, Evan ;

Sullivan, Thomas .

JOURNAL OF SEXUAL MEDICINE, 2012, 9 (06) :1497-1507

← 1 2 3 4 5 6 7 8 9 10 →