Tapered-Fiber Optical Sensor for Physiological pH Range

被引:13
作者
Cui, Qingsong [1 ,2 ]
Podrazky, Ondrej [2 ]
Mrazek, Jan [2 ]
Probostova, Jana [2 ]
Kasik, Ivan [2 ]
机构
[1] Harbin Inst Technol, Inst Optoelect, Harbin 150001, Peoples R China
[2] ASCR, Vvi, Inst Photon & Elect, Prague 18251, Czech Republic
基金
中国博士后科学基金;
关键词
pH; HPTS; fluorescence; ratiometric; immobilization; FLUORESCENCE; FLUOROSENSOR; INDICATORS;
D O I
10.1109/JSEN.2015.2432091
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Optical sensors brings new possibilities to biological, medical, and environmental applications, since they are small, immune to electromagnetic field and their potential unwanted interaction with measured samples is limited. This paper describes influence of composition of pH-sensitive layers to their performance and application of these layers in a tapered-fiber optical pH sensor. The sensitive layers were based on ion-pair of 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt and hexadecyltrimethylammonium bromide, which was immobilized in xerogel matrices composed of ethyltriethoxysilane (ETES) and (3-glycidoxypropyl)-trimethoxysilane (GLYMO) in different ratios. The best performance was obtained for layers with ETES: GLYMO ratio of 40:60. Their detection range was in the interval of pH from 5.75 to 7.25. Proved stability of sols and coated optical substrates makes the practical application of these sensing layers feasible and the tested tapered-fiber probes are suitable for detection of small samples of volumes of microliters.
引用
收藏
页码:4967 / 4973
页数:7
相关论文
共 21 条
  • [11] Fiber-optic pH detection in small volumes of biosamples
    Kasik, I.
    Mrazek, J.
    Martan, T.
    Pospisilova, M.
    Podrazky, O.
    Matejec, V.
    Hoyerova, K.
    Kaminek, M.
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 398 (05) : 1883 - 1889
  • [12] In vivo optical detection of pH in microscopic tissue samples of Arabidopsis thaliana
    Kasik, Ivan
    Podrazky, Ondrej
    Mrazek, Jan
    Martan, Tomas
    Matejec, Vlastimil
    Hoyerova, Klara
    Kaminek, Miroslav
    [J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (08): : 4809 - 4815
  • [13] Dual excitation ratiometric fluorescent pH sensor for noninvasive bioprocess monitoring: Development and application
    Kermis, HR
    Kostov, Y
    Harms, P
    Rao, G
    [J]. BIOTECHNOLOGY PROGRESS, 2002, 18 (05) : 1047 - 1053
  • [14] Lakowicz J. R., 2006, PRINCIPLES FLUORESCE, DOI 10.1007/978-0-387-46312-4
  • [15] Lifetime-based pH sensors: Indicators for acidic environments
    Lin, HJ
    Szmacinski, H
    Lakowicz, JR
    [J]. ANALYTICAL BIOCHEMISTRY, 1999, 269 (01) : 162 - 167
  • [16] pH optical sensors based on sol-gels: Chemical doping versus covalent immobilization
    Lobnik, A
    Oehme, I
    Murkovic, I
    Wolfbeis, OS
    [J]. ANALYTICA CHIMICA ACTA, 1998, 367 (1-3) : 159 - 165
  • [17] Sol-gel immobilised ruthenium(II) polypyridyl complexes as chemical transducers for optical pH sensing
    Malins, C
    Glever, HG
    Keyes, TE
    Vos, JG
    Dressick, WJ
    MacCraith, BD
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2000, 67 (1-2) : 89 - 95
  • [18] DEPENDENCE OF THE FLUORESCENCE OF IMMOBILIZED 1-HYDROXYPYRENE-3,6,8-TRISULFONATE ON SOLUTION PH - EXTENSION OF THE RANGE OF APPLICABILITY OF A PH FLUOROSENSOR
    SCHULMAN, SG
    CHEN, SX
    BAI, FL
    LEINER, MJP
    WEIS, L
    WOLFBEIS, OS
    [J]. ANALYTICA CHIMICA ACTA, 1995, 304 (02) : 165 - 170
  • [19] Fiber-Optic Chemical Sensors and Biosensors (2008-2012)
    Wang, Xu-Dong
    Wolfbeis, Otto S.
    [J]. ANALYTICAL CHEMISTRY, 2013, 85 (02) : 487 - 508
  • [20] High performance optical ratiometric sol-gel-based pH sensor
    Wencel, D.
    MacCraith, B. D.
    McDonagh, C.
    [J]. SENSORS AND ACTUATORS B-CHEMICAL, 2009, 139 (01) : 208 - 213