Chromatin Mechanisms Driving Cancer

被引：14

作者：

Gryder, Berkley ^{[1
,2
]}

Scacheri, Peter C. ^{[1
]}

Ried, Thomas ^{[2
]}

Khan, Javed ^{[2
]}

机构：

[1] Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA

[2] NCI, Genet Branch, Ctr Canc Res, Bethesda, MD 20892 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2022年 / 14卷 / 03期

关键词：

TRANSCRIPTION FACTORS; SUPER-ENHANCERS; GENOMIC ANALYSIS; BAF COMPLEXES; MUTATIONS; REVEALS; ONCOGENE; GAIN; GENE; INHIBITION;

D O I：

10.1101/cshperspect.a040956

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The change in cell state from normal to malignant is driven fundamentally by oncogenic mutations in cooperation with epigenetic alterations of chromatin. These alterations in chromatin can be a consequence of environmental stressors or germline and/or somatic mutations that directly alter the structure of chromatin machinery proteins, their levels, or their regulatory function. These changes can result in an inability of the cell to differentiate along a predefined lineage path, or drive a hyperactive, highly proliferative state with addiction to high levels of transcriptional output. We discuss how these genetic alterations hijack the chromatin machinery for the oncogenic process to reveal unique vulnerabilities and novel targets for cancer therapy.

引用

页数：19

共 145 条

[71] Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains [J].

Kwon, Ilmin ;

Kato, Masato ;

Xiang, Siheng ;

Wu, Leeju ;

Theodoropoulos, Pano ;

Mirzaei, Hamid ;

Han, Tina ;

Xie, Shanhai ;

Corden, Jeffry L. ;

McKnight, Steven L. .

CELL, 2013, 155 (05) :1049-1060

[72] The MYC Enhancer-ome: Long-Range Transcriptional Regulation of MYC in Cancer [J].

Lancho, Olga ;

Herranz, Daniel .

TRENDS IN CANCER, 2018, 4 (12) :810-822

[73] Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours [J].

Lasko, Loren M. ;

Jakob, Clarissa G. ;

Edalji, Rohinton P. ;

Qiu, Wei ;

Montgomery, Debra ;

Digiammarino, Enrico L. ;

Hansen, T. Matt ;

Risi, Roberto M. ;

Frey, Robin ;

Manaves, Vlasios ;

Shaw, Bailin ;

Algire, Mikkel ;

Hessler, Paul ;

Lam, Lloyd T. ;

Uziel, Tamar ;

Faivre, Emily ;

Ferguson, Debra ;

Buchanan, Fritz G. ;

Martin, Ruth L. ;

Torrent, Maricel ;

Chiang, Gary G. ;

Karukurichi, Kannan ;

Langston, J. William ;

Weinert, Brian T. ;

Choudhary, Chunaram ;

de Vries, Peter ;

Van Drie, John H. ;

McElligott, David ;

Kesicki, Ed ;

Marmorstein, Ronen ;

Sun, Chaohong ;

Cole, Philip A. ;

Rosenberg, Saul H. ;

Michaelides, Michael R. ;

Lai, Albert ;

Bromberg, Kenneth D. .

NATURE, 2017, 550 (7674) :128-+

[74] Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma [J].

Lewis, Peter W. ;

Mueller, Manuel M. ;

Koletsky, Matthew S. ;

Cordero, Francisco ;

Lin, Shu ;

Banaszynski, Laura A. ;

Garcia, Benjamin A. ;

Muir, Tom W. ;

Becher, Oren J. ;

Allis, C. David .

SCIENCE, 2013, 340 (6134) :857-861

[75] The role of chromatin during transcription [J].

Li, Bing ;

Carey, Michael ;

Workman, Jerry L. .

CELL, 2007, 128 (04) :707-719

[76] Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome [J].

Lieberman-Aiden, Erez ;

van Berkum, Nynke L. ;

Williams, Louise ;

Imakaev, Maxim ;

Ragoczy, Tobias ;

Telling, Agnes ;

Amit, Ido ;

Lajoie, Bryan R. ;

Sabo, Peter J. ;

Dorschner, Michael O. ;

Sandstrom, Richard ;

Bernstein, Bradley ;

Bender, M. A. ;

Groudine, Mark ;

Gnirke, Andreas ;

Stamatoyannopoulos, John ;

Mirny, Leonid A. ;

Lander, Eric S. ;

Dekker, Job .

SCIENCE, 2009, 326 (5950) :289-293

[77] AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia [J].

Lin, Chengqi ;

Smith, Edwin R. ;

Takahashi, Hidehisa ;

Lai, Ka Chun ;

Martin-Brown, Skylar ;

Florens, Laurence ;

Washburn, Michael P. ;

Conaway, Joan W. ;

Conaway, Ronald C. ;

Shilatifard, Ali .

MOLECULAR CELL, 2010, 37 (03) :429-437

[78] An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element [J].

Mansour, Marc R. ;

Abraham, Brian J. ;

Anders, Lars ;

Berezovskaya, Alla ;

Gutierrez, Alejandro ;

Durbin, Adam D. ;

Etchin, Julia ;

Lawton, Lee ;

Sallan, Stephen E. ;

Silverman, Lewis B. ;

Loh, Mignon L. ;

Hunger, Stephen P. ;

Sanda, Takaomi ;

Young, Richard A. ;

Look, A. Thomas .

SCIENCE, 2014, 346 (6215) :1373-1377

[79]

MARK J, 1967, HEREDITAS-GENETISK A, V57, P1

[80] NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency [J].

Marques, Joana G. ;

Gryder, Berkley E. ;

Pavlovic, Blaz ;

Chung, Yeonjoo ;

Ngo, Quy A. ;

Frommelt, Fabian ;

Gstaiger, Matthias ;

Song, Young ;

Benischke, Katharina ;

Laubscher, Dominik ;

Wachtel, Marco ;

Khan, Javed ;

Schafer, Beat W. .

ELIFE, 2020, 9

← 3 4 5 6 7 8 9 10 11 12 →