Health-related quality of life and burden of fatigue in patients with primary immune thrombocytopenia by phase of disease

被引:67
作者
Efficace, Fabio [1 ,2 ]
Mandelli, Franco [1 ,2 ]
Fazi, Paola [1 ,2 ]
Santoro, Cristina [3 ]
Gaidano, Gianluca [4 ]
Cottone, Francesco [1 ,2 ]
Borchiellini, Alessandra [5 ,6 ]
Carpenedo, Monica [7 ]
Simula, Maria Pina [8 ]
Di Giacomo, Valeria [9 ]
Bergamaschi, Micaela [10 ]
Vincelli, Iolanda Donatella [11 ]
Rodeghiero, Francesco [12 ]
Ruggeri, Marco [13 ]
Scaramucci, Laura [14 ]
Rambaldi, Alessandro [15 ]
Cascavilla, Nicola [16 ,17 ]
Forghieri, Fabio [18 ]
Petrungaro, Annamaria [19 ]
Ditonno, Paolo [20 ]
Caocci, Giovanni [21 ]
Cirrincione, Sonia [22 ]
Mazzucconi, Maria Gabriella [3 ]
机构
[1] Italian Grp Adult Hematol Dis GIMEMA, Ctr Data, Rome, Italy
[2] Hlth Outcomes Res Unit, Rome, Italy
[3] Univ Rome Sapienza, Dept Cellular Biotechnol & Hematol, Rome, Italy
[4] Univ Piemonte Orientale, Div Hematol, Dept Translat Med, Novara, Italy
[5] Citta Salute & Sci, Hemostasis Thrombosis Unit, Turin, Italy
[6] Citta Salute & Sci, Hemophilia Ctr, Turin, Italy
[7] Univ Milano Bicocca, San Gerardo Hosp, Hematol & Bone Marrow Transplantat, Monza, Italy
[8] Osped Oncol Riferimento Reg Armando Businco, Hematol & Bone Marrow Transplantat Unit, Cagliari, Italy
[9] Div Hematol, Azienda Osped Papardo, Messina, Italy
[10] Clin Ematol IRCCS AOU San Martino IST, Genoa, Italy
[11] Azienda Osped Bianchi Melacrino Morelli, Hematol, Reggio Di Calabria, Italy
[12] Hematol Project Fdn, Vicenza, Italy
[13] San Bortolo Hosp, Dept Cell Therapy & Hematol, Vicenza, Italy
[14] S Eugenio Hosp, Dept Haematol, Rome, Italy
[15] Univ Milan, Hematol & Bone Marrow Transplant Unit, ASST Osped Papa Giovanni 23, Dept Sci Clin & Comunita, Bergamo, Italy
[16] IRCCS Casa Sollievo Della Sofferenza Hosp, Dept Hematol, San Giovanni Rotondo, Italy
[17] IRCCS Casa Sollievo Della Sofferenza Hosp, Stem Cell Transplantat Unit, San Giovanni Rotondo, Italy
[18] Univ Modena & Reggio Emilia, Azienda Osped Univ Policlin, Dept Oncol Hematol & Resp Dis, Sect Hematol, Modena, Italy
[19] Univ Messina, Div Hematol, Messina, Italy
[20] Di Venere Hosp, Hematol Unit, Bari, Italy
[21] Univ Cagliari, Dept Med Sci, Cagliari, Italy
[22] Treviglio Hosp, Unit Transfus & Hematol, Treviglio, Italy
关键词
PURPURA; ROMIPLOSTIM; ADULTS; SF-36; QUESTIONNAIRE; STANDARD; CHILDREN;
D O I
10.1002/ajh.24463
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The main objective of this study was to compare health-related quality of life (HRQOL) of primary immune thrombocytopenia (pITP) patients with that of general population, overall, and by patient group (i.e., newly diagnosed, persistent, and chronic patients). Fatigue was also investigated as a secondary objective. Overall, 424 adult patients were enrolled in a multicenter observational study and the control group consisted of a representative sample from the general population. Propensity score matching plus further multivariate linear regression adjustment was used to compare HRQOL outcomes between pITP patients and general population. Mean age of patients was 54 years. Of those with HRQOL assessment, 99 patients (23.6%) were newly diagnosed, 53 (12.6%) were persistent, and 268 (63.8%) were chronic pITP patients. Comparison by patient group versus their respective peers in the general population revealed greater impairments in persistent pITP patients. Persistent pITP patients reported clinically meaningful impairments in physical functioning (-15; 95% CI -24.1 to -5.8; P = 0.002), social functioning (-15.3; 95% CI -25.5 to -5.1; P = 0.004), role physical (-28.4; 95% CI -43.1 to -13.7; P < 0.001), role emotional (-23.9; 95% CI -40.1 to -7.7; P = 0.004), and mental health scales (-11.3; 95% CI -21.2 to -1.4; P = 0.026) of the SF-36 questionnaire. Higher fatigue severity was associated with lower physical and mental HRQOL outcomes. Our findings suggest that the burden of the disease and treatment might depend on the disease phase and that persistent pITP patients are the most vulnerable subgroup. (C) 2016 Wiley Periodicals, Inc.
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收藏
页码:995 / 1001
页数:7
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