Comorbid diagnoses for youth at clinical high risk of psychosis

被引：90

作者：

Addington, Jean ^{[1
]}

Piskulic, Danijela ^{[1
]}

Liu, Lu ^{[1
]}

Lockwood, Jonathan ^{[1
]}

Cadenhead, Kristin S. ^{[2
]}

Cannon, Tyrone D. ^{[3
]}

Cornblatt, Barbara A. ^{[4
]}

McGlashan, Thomas H. ^{[5
]}

Perkins, Diana O. ^{[6
]}

Seidman, Larry J. ^{[7
,8
]}

Tsuang, Ming T. ^{[2
,9
]}

Walker, Elaine F. ^{[10
]}

Bearden, Carrie E. ^{[11
,12
]}

Mathalon, Daniel H. ^{[13
,14
]}

Woods, Scott W. ^{[5
]}

机构：

[1] Univ Calgary, Dept Psychiat, Hotchkiss Brain Inst, Calgary, AB, Canada

[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[3] Yale Univ, Dept Psychol, New Haven, CT USA

[4] Zucker Hillside Hosp, Dept Psychiat, Queens, NY USA

[5] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA

[6] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA

[7] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA USA

[8] Massachusetts Gen Hosp, Boston, MA 02114 USA

[9] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA

[10] Emory Univ, Dept Psychol, Atlanta, GA 30322 USA

[11] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

[12] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[13] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[14] Psychiat Serv, San Francisco, CA USA

来源：

SCHIZOPHRENIA RESEARCH | 2017年 / 190卷

关键词：

Clinical high risk; DSM-IV diagnoses; Comorbidity; Anxiety; Depression; ULTRA-HIGH RISK; LONGITUDINAL DATA-ANALYSIS; CANNABIS USE; PRODROME; INDIVIDUALS; TRANSITION; DISORDERS; VALIDITY; OUTCOMES; STATE;

D O I：

10.1016/j.schres.2017.03.043

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Several studies have demonstrated that youth at clinical high risk (CHR) of developing psychosis have a high prevalence of comorbid psychiatric disorders. Less is known about the impact of comorbid diagnoses on later conversion to psychosis and the change over time. The aim of this study was to determine the frequency and distribution of psychiatric diagnoses at baseline and over time in the North American Prodrome Longitudinal Study (NAPLS 2) and the role of comorbid diagnoses in conversion to psychosis. The NAPLS 2 sample consisted of 744 CHR youth and 276 healthy controls. Only 21% of the CHR group did not have a comorbid diagnosis with many have 2-3 DSM-IV comorbid diagnoses. The most common diagnoses were anxiety and depressive disorders, which did improve over time. The only diagnosis at baseline that differentiated the converters from the non-converters was cannabis misuse. Comorbidity, except for cannabis use, was essentially independent of clinical outcome. It is possible that those with comorbid diagnoses are preferentially the help-seeking individuals that present for help in our clinics and research projects and that those who are at risk but do not have a comorbid diagnosis may not be seeking help in the prodromal phase. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：90 / 95

页数：6

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