Synthesis of a functionalized salen copper complex and its interaction with DNA

被引：106
作者：
Routier, S
Bernier, JL
Waring, MJ
Colson, P
Houssier, C
Bailly, C
机构：
[1] UNIV SCI & TECH LILLE FLANDRES ARTOIS,URA CNRS 351,CHIM ORGAN PHYS LAB,F-59655 VILLENEUVE DASCQ,FRANCE
[2] UNIV CAMBRIDGE,DEPT PHARMACOL,CAMBRIDGE CB2 1QJ,ENGLAND
[3] UNIV LIEGE,LAB CHIM MACROMOLEC & CHIM PHYS,B-4000 LIEGE,BELGIUM
[4] INST RECH CANC,INSERM U124,F-59045 LILLE,FRANCE
来源：
JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 07期
关键词：
D O I：
10.1021/jo951840c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An original procedure for efficient synthesis of a functionalized salen copper complex is reported. The mode of binding to DNA of the salen . Cu-II complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen . Cu-II complex induces single-stranded breaks via an interaction within one of the grooves of the double helix.
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页码：2326 / 2331
页数：6
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