Synthesis of a functionalized salen copper complex and its interaction with DNA

被引：106

作者：

Routier, S

Bernier, JL

Waring, MJ

Colson, P

Houssier, C

Bailly, C

机构：

[1] UNIV SCI & TECH LILLE FLANDRES ARTOIS,URA CNRS 351,CHIM ORGAN PHYS LAB,F-59655 VILLENEUVE DASCQ,FRANCE

[2] UNIV CAMBRIDGE,DEPT PHARMACOL,CAMBRIDGE CB2 1QJ,ENGLAND

[3] UNIV LIEGE,LAB CHIM MACROMOLEC & CHIM PHYS,B-4000 LIEGE,BELGIUM

[4] INST RECH CANC,INSERM U124,F-59045 LILLE,FRANCE

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 07期

关键词：

D O I：

10.1021/jo951840c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An original procedure for efficient synthesis of a functionalized salen copper complex is reported. The mode of binding to DNA of the salen . Cu-II complex was investigated by viscometry as well as by absorption, circular, and linear dichroism spectroscopy. The complex can induce DNA strand breakage in the presence of a reducing agent as revealed by a plasmid cleavage assay. The spectroscopic and biochemical data indicate that the salen . Cu-II complex induces single-stranded breaks via an interaction within one of the grooves of the double helix.

引用

页码：2326 / 2331

页数：6

共 32 条

[1] POTENTIAL ANTI-TUMOR AGENTS .34. QUANTITATIVE RELATIONSHIPS BETWEEN DNA-BINDING AND MOLECULAR-STRUCTURE FOR 9-ANILINOACRIDINES SUBSTITUTED IN THE ANILINO RING [J].