Non-Small-Cell Lung Cancer in 2022: A Review for General Practitioners in Oncology

被引：240

作者：

Mithoowani, Hamid ^{[1
]}

Febbraro, Michela ^{[2
]}

机构：

[1] Grand River Reg Canc Ctr, 835 King St W, Kitchener, ON N2G 1G3, Canada

[2] Hamilton Hlth Sci Ctr, Juravinski Canc Ctr, 699 Concess St, Hamilton, ON L8V 5C2, Canada

来源：

CURRENT ONCOLOGY | 2022年 / 29卷 / 03期

关键词：

non-small cell lung cancer; lung cancer; screening; immunotherapy; iRAE; iRAEs; CAGPO; Canadian Association of General Practitioners in Oncology; ALK; EGFR; K-RAS; KRAS; OPEN-LABEL; SINGLE-ARM; CHEMOTHERAPY; OSIMERTINIB; CHEMORADIOTHERAPY; MULTICENTER; CRIZOTINIB; MUTATIONS; NIVOLUMAB; SELECTION;

D O I：

10.3390/curroncol29030150

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lung cancer is the leading cause of cancer death in Canada and a significant cause of morbidity for patients and their loved ones. There have been rapid advances in preventing, screening and treating this disease. Here, we present a contemporary review of treatment of non-small cell lung cancer in Canada based on current best practices. The focus of this review is to highlight recent data in screening for lung cancer, management of patients with early and locally-advanced non-small cell lung cancer, as well as management of patients with metastatic disease. There is a special focus on the incorporation of immunotherapy into practice and its associated toxicities.

引用

页码：1828 / 1839

页数：12

共 66 条

[61] Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials A Systematic Review and Meta-analysis [J].

Wang, Yucai ;

Zhou, Shouhao ;

Yang, Fang ;

Qi, Xinyue ;

Wang, Xin ;

Guan, Xiaoxiang ;

Shen, Chan ;

Duma, Narjust ;

Aguilera, Jesus Vera ;

Chintakuntlawar, Ashish ;

Price, Katharine A. ;

Molina, Julian R. ;

Pagliaro, Lance C. ;

Halfdanarson, Thorvardur R. ;

Grothey, Axel ;

Markovic, Svetomir N. ;

Nowakowski, Grzegorz S. ;

Ansel, Stephen M. ;

Wang, Michael L. .

JAMA ONCOLOGY, 2019, 5 (07) :1008-1019

[62] Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer [J].

Wu, Yi-Long ;

Tsuboi, Masahiro ;

He, Jie ;

John, Thomas ;

Grohe, Christian ;

Majem, Margarita ;

Goldman, Jonathan W. ;

Laktionov, Konstantin ;

Kim, Sang-We ;

Kato, Terufumi ;

Vu, Huu-Vinh ;

Lu, Shun ;

Lee, Kye-Young ;

Akewanlop, Charuwan ;

Yu, Chong-Jen ;

de Marinis, Filippo ;

Bonanno, Laura ;

Domine, Manuel ;

Shepherd, Frances A. ;

Zeng, Lingmin ;

Hodge, Rachel ;

Atasoy, Ajlan ;

Rukazenkov, Yuri ;

Herbst, Roy S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (18) :1711-1723

[63] Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6 [J].

Yang, James C-H ;

Sequist, Lecia V. ;

Geater, Sarayut Lucien ;

Tsai, Chun-Ming ;

Mok, Tony Shu Kam ;

Schuler, Martin ;

Yamamoto, Nobuyuki ;

Yu, Chong-Jen ;

Ou, Sai-Hong I. ;

Zhou, Caicun ;

Massey, Daniel ;

Zazulina, Victoria ;

Wu, Yi-Long .

LANCET ONCOLOGY, 2015, 16 (07) :830-838

[64] Interventions for smoking cessation in people diagnosed with lung cancer [J].

Zeng, Linmiao ;

Yu, Xiaolian ;

Yu, Tingting ;

Xiao, Jianhong ;

Huang, Yushan .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2019, (06)

[65] Treatment Outcomes and Safety of Mobocertinib in Platinum-Pretreated Patients With EGFR Exon 20 Insertion-Positive Metastatic Non-Small Cell Lung Cancer A Phase 1/2 Open-label Nonrandomized Clinical Trial [J].

Zhou, Caicun ;

Ramalingam, Suresh S. ;

Kim, Tae Min ;

Kim, Sang-We ;

Yang, James Chih-Hsin ;

Riely, Gregory J. ;

Mekhail, Tarek ;

Nguyen, Danny ;

Campelo, Maria R. Garcia ;

Felip, Enriqueta ;

Vincent, Sylvie ;

Jin, Shu ;

Griffin, Celina ;

Bunn, Veronica ;

Lin, Jianchang ;

Lin, Huamao M. ;

Mehta, Minal ;

Janne, Pasi A. .

JAMA ONCOLOGY, 2021, 7 (12) :1772-1781

[66] Alectinib versus crizotinib in untreated Asian patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer (ALESIA): a randomised phase 3 study [J].

Zhou, Caicun ;

Kim, Sang-We ;

Reungwetwattana, Thanyanan ;

Zhou, Jianying ;

Zhang, Yiping ;

He, Jianxing ;

Yang, Jin-Ji ;

Cheng, Ying ;

Lee, Se-Hoon ;

Bu, Lilian ;

Xu, Tingting ;

Yang, Li ;

Wang, Chao ;

Liu, Ting ;

Morcos, Peter N. ;

Lu, You ;

Zhang, Li .

LANCET RESPIRATORY MEDICINE, 2019, 7 (05) :437-446

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