Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper

被引：73

作者：

Barbaud, Annick ^{[1
]}

Garvey, Lene Heise ^{[2
,3
]}

Arcolaci, Alessandra ^{[4
]}

Brockow, Knut ^{[5
]}

Mori, Francesca ^{[6
]}

Mayorga, Cristobalina ^{[7
]}

Bonadonna, Patrizia ^{[8
]}

Atanaskovic-Markovic, Marina ^{[9
]}

Moral, Luis ^{[10
]}

Zanoni, Giovanna ^{[11
]}

Pagani, Mauro ^{[12
]}

Soria, Angele ^{[13
]}

Jost, Maja ^{[14
]}

Caubet, Jean-Christoph ^{[15
]}

Carmo, Abreu ^{[16
]}

Mona, Al-Ahmad ^{[17
]}

Alvarez-Perea, Alberto ^{[18
]}

Bavbek, Sevim ^{[19
]}

Benedetta, Biagioni ^{[20
]}

Bilo, M. Beatrice ^{[21
,22
]}

Blanca-Lopez, Natalia ^{[23
]}

Bogas, Herrera Gador ^{[24
,25
]}

Buonomo, Alessandro ^{[26
]}

Calogiuri, Gianfranco ^{[27
]}

Carli, Giulia ^{[28
]}

Cernadas, Josefina ^{[29
,30
]}

Cortellini, Gabriele ^{[31
]}

Celik, Gulfem ^{[32
]}

Demir, Semra ^{[33
]}

Dona, Inmaculada ^{[34
]}

Dursun, Adile Berna ^{[35
]}

Eberlein, Bernadette ^{[5
]}

Faria, Emilia ^{[36
]}

Fernandes, Bryan ^{[37
]}

Garcez, Tomaz ^{[38
]}

Garcia-Nunez, Ignacio ^{[39
]}

Gawlik, Radoslaw ^{[40
]}

Gelincik, Asli ^{[33
]}

Gomes, Eva ^{[41
]}

Gooi, Jimmy H. C. ^{[42
]}

Grosber, Martine ^{[43
]}

Gulen, Theo ^{[44
]}

Hacard, Florence ^{[45
]}

Hoarau, Cyrille ^{[46
]}

Janson, Christer ^{[47
]}

Johnston, Sebastian L. ^{[48
]}

Joerg, Lukas ^{[49
]}

Ozdemir, Secil Kepil ^{[50
]}

Klimek, Ludger ^{[51
]}

Kosnik, Mitja ^{[52
]}

机构：

[1] Sorbonne Univ, INSERM, Inst Pierre Louis Epidemiol & Sante Publ, Hop Tenon,AP HP,Dept Dermatol & Allergol, F-75020 Paris, France

[2] Copenhagen Univ Hosp Gentofte, Allergy Clin, Copenhagen, Denmark

[3] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[4] Univ Hosp Verona, Immunol Unit, Policlin GB Rossi, Verona, Italy

[5] Tech Univ Munich, Fac Med, Dept Dermatol & Allergy Biederstein, Munich, Germany

[6] Meyer Childrens Univ Hosp, Dept Pediat, Allergy Unit, Florence, Italy

[7] Hosp Reg Univ Malaga, Allergy Clin Unit, Inst Invest Biomed Malaga IBIMA, ARADyAL, Malaga, Spain

[8] Verona Univ Hosp, Allergy Unit, Verona, Italy

[9] Univ Belgrade, Univ Childrens Hosp, Fac Med, Belgrade, Serbia

[10] Alicante Univ Gen Hosp, Alicante Inst Hlth & Biomed Res ISABIAL, Pediat Allergy & Resp Unit, Alicante, Spain

[11] Azienda Osped Univ Integrata Verona, Immunol Unit, Policlin GB Rossi, Verona, Italy

[12] ASST Mantova, Med Dept, Med Ward Mantova Hosp, Mantua, Italy

[13] Sorbonne Univ, INSERM 1135 Cimi Paris, Hop Tenon, Assistance Publ Hop Paris,Dept Dermatol & Allergo, Paris, France

[14] Univ Clin Resp & Allerg Dis Golnik, Golnik, Slovenia

[15] Univ Hosp Geneva, Dept Women Children Teenagers, Geneva, Switzerland

[16] Ctr Hosp Tras Os Montes & Alto Douro, Ctr Hosp Baixo Vouga, Allergy & Clin Immunol Unit, Vila Real & Allergy & Clin Immunol Unit, Aveiro, Portugal

[17] Kuwait Univ, Fac Med, Microbiol Dept, Kuwait, Kuwait

[18] Hosp Gen Univ Gregorio Maranon, Allergy Dept, Madrid, Spain

[19] Ankara Univ, Sch Med, Dept Pulm Dis, Div Allergy,FAAAI, Ankara, Turkey

[20] IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, Bologna, Italy

[21] Univ Politecn Marche, Dept Clin & Mol Sci, Ancona, Italy

[22] Univ Hosp Osped Riuniti Ancona, Allergy Unit, Dept Internal Med, Ancona, Italy

[23] Infanta Leonor Univ Hosp, Madrid, Spain

[24] Hosp Reg Univ Malaga HRUM, Inst Invest Biomed Malaga IBIMA, Allergy Res Grp, Malaga, Spain

[25] Hosp Reg Univ Malaga HRUM, Allergy Unit, Malaga, Spain

[26] Fdn Policlin Gemelli IRCCS Largo Gemelli, Allergy Unit, Rome, Italy

[27] Hosp Vito Fazzi, Lecce, Italy

[28] Azienda USL Toscana Ctr, Osped S Stefano, SOS Allergol & Immunol, Prato, Italy

[29] Ctr Hosp Univ S Joao, Allergy & Clin Immunol Dept, Porto, Portugal

[30] Hosp Lusiadas, Allergy Unit, Porto, Portugal

[31] Azienda Sanitaria Romagna, Rimini Hosp, Allergy Unit, Dept Internal Med, Rimini, Italy

[32] Ankara Univ, Dept Chest Dis, Div Immunol & Allergy, Sch Med,Cebeci Hosp, Ankara, Turkey

[33] Istanbul Univ, Istanbul Fac Med Internal Med Immunol & Allerg Di, Istanbul, Turkey

[34] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Allergy Unit, Allergy Res Grp, Plaza Hosp Civil S-N, Malaga, Spain

[35] Mem Ankara Hosp, Dept Adult Allergy, Ankara, Turkey

[36] Ctr Hosp & Univ Coimbra, Allergy & Clin Immunol Unit, Coimbra, Portugal

[37] Barts Hlth NHS Trust, St Bartholomews Hosp, London, England

[38] Manchester Univ NHS Fdn Trust, Immunol Dept, Manchester, Lancs, England

[39] Hosp Quironsalud Cordoba, Cordoba, Spain

[40] Med Univ Silesia, Dept Internal Dis Allergol & Clin Immunol, Katowice, Poland

[41] Ctr Hosp Univ Porto, Allergy Dept, Porto, Portugal

[42] Kings Coll Hosp London, Dept Clin Immunol, London, England

[43] Vrije Univ Brussel, Univ Ziekenhuis, Dept Dermatol, Brussels, Belgium

[44] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Resp Med & Allergy, Dept Med, Stockholm, Sweden

[45] Ctr Hosp Lyon Sud, Allergol & Clin Immunol Dept, Pierre Benite, France

[46] CHR Tours, Serv Transversal Allergol & Immunol Clin, Tours, France

[47] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[48] Imperial Coll London, Natl Heart & Lung Inst, London, England

[49] Univ Bern, Bern Univ Hosp, Dept Pneumol, Div Allergol & Clin Immunol,Inselspital, Bern, Switzerland

[50] Chest Dis & Surg Training & Res Hosp, Dept Chest Dis, Div Allergy & Immunol, Izmir, Turkey

来源：

ALLERGY | 2022年 / 77卷 / 08期

关键词：

allergy test; anaphylaxis; COVID-19; vaccine; mRNA vaccines; risk assessment; ANTI-PEG ANTIBODIES; POLYETHYLENE-GLYCOL; HYPERSENSITIVITY REACTIONS; MACROGOL HYPERSENSITIVITY; CONTACT SENSITIZATION; ANAPHYLACTIC REACTION; SAFETY; MULTICENTER; VACCINATION;

D O I：

10.1111/all.15241

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized. Method Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed. Results No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable. Conclusions These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.

引用

页码：2292 / 2312

页数：21

共 71 条

[1] Allergic contact dermatitis caused by PEG-22/dodecyl glycol copolymer in a skin-repairing cream [J].

Amsler, Emmanuelle ;

Al-Raddadi, Reem ;

Frances, Camille .

CONTACT DERMATITIS, 2017, 77 (01) :54-55

[2] Allergic reaction to polyethylene glycol in a painter [J].

Antolin-Amerigo, D. ;

Sanchez-Gonzalez, M. J. ;

Barbarroja-Escudero, J. ;

Rodriguez-Rodriguez, M. ;

Alvarez-Perea, A. ;

Alvarez-Mon, M. .

OCCUPATIONAL MEDICINE-OXFORD, 2015, 65 (06) :502-504

[3] Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients [J].

Armstrong, Jonathan K. ;

Hempel, Georg ;

Koling, Susanne ;

Chan, Linda S. ;

Fisher, Timothy ;

Meiselman, Herbert J. ;

Garratty, George .

CANCER, 2007, 110 (01) :103-111

[4] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[5]

Badiu I, 2012, ALLERGY, V67, P254, DOI 10.1136/bcr.02.2012.5797

[6] mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach [J].

Banerji, Aleena ;

Wickner, Paige G. ;

Saff, Rebecca ;

Stone, Cosby A. ;

Robinson, Lacey B. ;

Long, Aidan A. ;

Wolfson, Anna R. ;

Williams, Paul ;

Khan, David A. ;

Phillips, Elizabeth ;

Blumenthal, Kimberly G. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2021, 9 (04) :1423-1437

[7] Intradermal Tests With Drugs: An Approach to Standardization [J].

Barbaud, Annick ;

Weinborn, Marie ;

Garvey, Lene Heise ;

Testi, Sergio ;

Kvedariene, Violeta ;

Bavbek, Sevim ;

Mosbech, Holger ;

Gomes, Eva ;

Aberer, Werner ;

Elberink, Hanneke N. G. Oude ;

Jose Torres, Maria ;

Ponvert, Claude ;

Ayav, C. ;

Gooi, Jimmy ;

Brockow, Knut .

FRONTIERS IN MEDICINE, 2020, 7

[8] Contact allergy in chronic leg ulcers: results of a multicentre study carried out in 423 patients and proposal for an updated series of patch tests [J].

Barbaud, Annick ;

Collet, Evelyne ;

Le Coz, Christophe J. ;

Meaume, Sylvie ;

Gillois, Pierre .

CONTACT DERMATITIS, 2009, 60 (05) :279-287

[9] MACROGOL HYPERSENSITIVITY IN MULTIPLE DRUG ALLERGY [J].

Bommarito, Luisa ;

Mietta, Sabrina ;

Nebiolo, Franco ;

Geuna, Massimo ;

Rolla, Giovanni .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2011, 107 (06) :542-543

[10] COVID-19 Vaccination in Mastocytosis: Recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM) [J].

Bonadonna, Patrizia ;

Brockow, Knut ;

Niedoszytko, Marek ;

Elberink, Hanneke Oude ;

Akin, Cem ;

Nedoszytko, Boguslaw ;

Butterfield, Joseph H. ;

Alvarez-Twose, Ivan ;

Sotlar, Karl ;

Schwaab, Juliana ;

Jawhar, Mohamad ;

Castells, Mariana ;

Sperr, Wolfgang R. ;

Hermine, Olivier ;

Gotlib, Jason ;

Zanotti, Roberta ;

Reiter, Andreas ;

Broesby-Olsen, Sigurd ;

Bindslev-Jensen, Carsten ;

Schwartz, Lawrence B. ;

Horny, Hans-Peter ;

Radia, Deepti ;

Triggiani, Massimo ;

Sabato, Vito ;

Carter, Melody C. ;

Siebenhaar, Frank ;

Orfao, Alberto ;

Grattan, Clive ;

Metcalfe, Dean D. ;

Arock, Michel ;

Gulen, Theo ;

Hartmann, Karin ;

Valent, Peter .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2021, 9 (06) :2139-2144

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