Analysis of the antibody structure based on high-resolution crystallographic studies

被引：34

作者：

Narciso, Jo Erika T. ^{[1
]}

Uy, Iris Diana C. ^{[1
]}

Cabang, April B. ^{[1
]}

Chavez, Jenina Faye C. ^{[1
]}

Pablo, Juan Lorenzo B. ^{[1
]}

Padilla-Concepcion, Gisela P. ^{[1
]}

Padlan, Eduardo A. ^{[1
]}

机构：

[1] Univ Philippines Diliman, Inst Marine Sci, Quezon City 1101, Philippines

来源：

NEW BIOTECHNOLOGY | 2011年 / 28卷 / 05期

关键词：

SINGLE-DOMAIN ANTIBODY; ANGSTROM RESOLUTION; HUMAN-IMMUNOGLOBULIN; AFFINITY MATURATION; CRYSTAL-STRUCTURES; FAB FRAGMENT; HIV-1; GP120; BINDING; COMPLEX; ANTIGEN;

D O I：

10.1016/j.nbt.2011.03.012

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

High-resolution structures of liganded and unliganded antibody molecules were analyzed in terms of the interaction between the antibody with ligand, between the residues in the contact between the variable domains, and between the framework and the complementarity-determining regions of the antibody. The solvent accessibilities of the residues in the variable domains were also analyzed. The structural information is useful in the engineering of antibodies for therapeutic and other purposes.

引用

页码：435 / 447

页数：13

共 37 条

[31] Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing Fabs [J].

Stanfield, RL ;

Cabezas, E ;

Satterthwait, AC ;

Stura, EA ;

Profy, AT ;

Wilson, IA .

STRUCTURE, 1999, 7 (02) :131-142

[32] Maturation of shark single-domain (IgNAR) antibodies: Evidence for induced-fit binding [J].

Stanfield, Robyn L. ;

Dooley, Helen ;

Verdino, Petra ;

Flajnik, Martin F. ;

Wilson, Ian A. .

JOURNAL OF MOLECULAR BIOLOGY, 2007, 367 (02) :358-372

[33] RESHAPING HUMAN-ANTIBODIES - GRAFTING AN ANTILYSOZYME ACTIVITY [J].

VERHOEYEN, M ;

MILSTEIN, C ;

WINTER, G .

SCIENCE, 1988, 239 (4847) :1534-1536

[34] AN ANALYSIS OF SEQUENCES OF VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY [J].

WU, TT ;

KABAT, EA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1970, 132 (02) :211-&

[35] Structural definition of a conserved neutralization epitope on HIV-1 gp120 [J].

Zhou, Tongqing ;

Xu, Ling ;

Dey, Barna ;

Hessell, Ann J. ;

Van Ryk, Donald ;

Xiang, Shi-Hua ;

Yang, Xinzhen ;

Zhang, Mei-Yun ;

Zwick, Michael B. ;

Arthos, James ;

Burton, Dennis R. ;

Dimitrov, Dimiter S. ;

Sodroski, Joseph ;

Wyatt, Richard ;

Nabel, Gary J. ;

Kwong, Peter D. .

NATURE, 2007, 445 (7129) :732-737

[36] Complete reaction cycle of a cocaine catalytic antibody at atomic resolution [J].

Zhu, XY ;

Dickerson, TJ ;

Rogers, CJ ;

Kaufmann, GF ;

Mee, JM ;

McKenzie, KM ;

Janda, KD ;

Wilson, IA .

STRUCTURE, 2006, 14 (02) :205-216

[37] Structural basis for antibody catalysis of a cationic cyclization reaction [J].

Zhu, XY ;

Heine, A ;

Monnat, F ;

Houk, KN ;

Janda, KD ;

Wilson, IA .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 329 (01) :69-83

← 1 2 3 4 →