Enhanced infarct myocardium repair mediated by thermosensitive copolymer hydrogel-based stem cell transplantation

被引：23

作者：

Xia, Yu ^{[1
,2
,3
]}

Zhu, Kai ^{[1
,2
]}

Lai, Hao ^{[1
,2
]}

Lang, Meidong ^{[4
]}

Xiao, Yan ^{[4
]}

Lian, Sheng ^{[4
]}

Guo, Changfa ^{[1
,2
]}

Wang, Chunsheng ^{[1
,2
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Cardiac Surg, Shanghai 200032, Peoples R China

[2] Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China

[3] Zunyi Med Coll, Affiliated Hosp, Dept Cardiothorac Surg, Zunyi 563003, Peoples R China

[4] E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 240卷 / 05期

基金：

美国国家科学基金会;

关键词：

Copolymer; hydrogel; mesenchymal stem cells; myocardial infarction; cardiac repair; INJECTABLE HYDROGEL; DELIVERY; HEART; MECHANISMS; SCAFFOLDS; THERAPY;

D O I：

10.1177/1535370214560957

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(epsilon-caprolactone) ratio of 88:9.6:2.4 was bioconjugated with type I collagen to construct a novel injectable thermosensitive hydrogel. The injectable and biocompatible hydrogel-mediated MSC transplantation could enhance the grafted cell survival in the myocardium, which contributed to the increased neovascularization, decreased interstitial fibrosis, and ultimately improved heart function to a significantly greater degree than regular MSC transplantation. We suggest that this novel hydrogel has the potential for future stem cell transplantation.

引用

页码：593 / 600

页数：8

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