Yttrium-90 for colorectal liver metastasis-the promising role of radiation segmentectomy as an alternative local cure

被引：15

作者：

Entezari, Pouya ^{[1
]}

Gabr, Ahmed ^{[1
]}

Salem, Riad ^{[1
,2
]}

Lewandowski, Robert J. ^{[1
,2
]}

机构：

[1] Northwestern Mem Hosp, Dept Radiol, Sect Intervent Radiol, 676 N St Clair,Suite 800, Chicago, IL 60611 USA

[2] Northwestern Univ, Comprehens Transplant Ctr, Dept Surg, Div Transplantat, Chicago, IL 60611 USA

来源：

INTERNATIONAL JOURNAL OF HYPERTHERMIA | 2022年 / 39卷 / 01期

关键词：

Colon cancer; metastatic liver disease; radioembolization; segmental radioembolization; radiation segmentectomy; RADIOFREQUENCY ABLATION; HEPATOCELLULAR-CARCINOMA; TUMOR PROGRESSION; SINGLE-CENTER; HEPATIC METASTASES; PLUS CHEMOTHERAPY; SURVIVAL OUTCOMES; RADIOEMBOLIZATION; CANCER; MICROSPHERES;

D O I：

10.1080/02656736.2021.1933215

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The majority of patients with metastatic colorectal cancer (CRC) to the liver are not amenable to curative-intent surgery or thermal ablation; there is a need for alternative locoregional therapies to control oligometastatic liver disease. Sequential lobar Yttrium-90 (Y90) radioembolization has demonstrated favorable results in the salvage setting for CRC patients with liver only or liver-dominant metastatic disease, but the role of Y90 in earlier-stage disease has not shown to be as promising. Recently, radiation segmentectomy, the super selective delivery of high (ablative) dose Y90 microspheres, has been introduced as a novel approach for patients with unresectable hepatocellular carcinoma. This review provides an overview of the current role of Y90 radioembolization for CRC patients with metastasis to the liver, with specific focus on the evolving application of radiation segmentectomy for patients with limited hepatic metastases from colorectal cancer.

引用

页码：620 / 626

页数：7

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