New leads for selective inhibitors of α-L-fucosidases.: Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives

被引：43
作者：
Robina, I [1 ]
Moreno-Vargas, AJ
Fernández-Bolaños, JG
Fuentes, J
Demange, R
Vogel, P
机构：
[1] Univ Seville, Fac Quim, Dept Quim Organ, E-41071 Seville, Spain
[2] Univ Lausanne, Chim Sect, BCH, CH-1015 Lausanne, Switzerland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 18期
关键词：
D O I：
10.1016/S0960-894X(01)00497-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Readily derived from D-glucose, 5-[(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]-2-methyl-3-furoic esters and amides are selective and competitive inhibitors (K(i)greater than or equal to3 muM) Of alpha -L-fucosidase from bovine epididymis and from human placenta. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：2555 / 2559
页数：5
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