Cell death: Critical control points

被引：3880
作者：
Danial, NN [1 ]
Korsmeyer, SJ [1 ]
机构：
[1] Harvard Univ, Howard Hughes Med Inst, Dana Farber Canc Inst, Sch Med, Boston, MA 02115 USA
来源：
CELL | 2004年 / 116卷 / 02期
关键词：
D O I：
10.1016/S0092-8674(04)00046-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
引用
收藏
页码：205 / 219
页数：15
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共 162 条
  • [91] IDENTIFICATION AND INHIBITION OF THE ICE/CED-3 PROTEASE NECESSARY FOR MAMMALIAN APOPTOSIS
    NICHOLSON, DW
    ALI, A
    THORNBERRY, NA
    VAILLANCOURT, JP
    DING, CK
    GALLANT, M
    GAREAU, Y
    GRIFFIN, PR
    LABELLE, M
    LAZEBNIK, YA
    MUNDAY, NA
    RAJU, SM
    SMULSON, ME
    YAMIN, TT
    YU, VL
    MILLER, DK
    [J]. NATURE, 1995, 376 (6535) : 37 - 43
  • [92] Nicotera P, 1997, Adv Neurol, V72, P95
  • [93] Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    Nijhawan, D
    Fang, M
    Traer, E
    Zhong, Q
    Gao, WH
    Du, FH
    Wang, XD
    [J]. GENES & DEVELOPMENT, 2003, 17 (12) : 1475 - 1486
  • [94] Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
    Oda, E
    Ohki, R
    Murasawa, H
    Nemoto, J
    Shibue, T
    Yamashita, T
    Tokino, T
    Taniguchi, T
    Tanaka, N
    [J]. SCIENCE, 2000, 288 (5468) : 1053 - 1058
  • [95] Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
    Olichon, A
    Baricault, L
    Gas, N
    Guillou, E
    Valette, A
    Belenguer, P
    Lenaers, G
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) : 7743 - 7746
  • [96] BCL-2 HETERODIMERIZES IN-VIVO WITH A CONSERVED HOMOLOG, BAX, THAT ACCELERATES PROGRAMMED CELL-DEATH
    OLTVAI, ZN
    MILLIMAN, CL
    KORSMEYER, SJ
    [J]. CELL, 1993, 74 (04) : 609 - 619
  • [97] Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    Opferman, JT
    Letai, A
    Beard, C
    Sorcinelli, MD
    Ong, CC
    Korsmeyer, SJ
    [J]. NATURE, 2003, 426 (6967) : 671 - 676
  • [98] Cytochrome c release from mitochondria proceeds by a two-step process
    Ott, M
    Robertson, JD
    Gogvadze, V
    Zhivotovsky, B
    Orrenius, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) : 1259 - 1263
  • [99] Mitochondrial endonuclease G is important for apoptosis in C-elegans
    Parrish, J
    Li, LL
    Klotz, K
    Ledwich, D
    Wang, XD
    Xue, D
    [J]. NATURE, 2001, 412 (6842) : 90 - 94
  • [100] Reduced loading of intracellular Ca2+ stores and downregulation of capacitative Ca2+ influx in Bcl-2-overexpressing cells
    Pinton, P
    Ferrari, D
    Magalhaes, P
    Schulze-Osthoff, K
    Di Virgilio, F
    Pozzan, T
    Rizzuto, R
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 148 (05) : 857 - 862
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