Cell death: Critical control points

被引：3903

作者：

Danial, NN ^{[1
]}

Korsmeyer, SJ ^{[1
]}

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Dana Farber Canc Inst, Sch Med, Boston, MA 02115 USA

来源：

CELL | 2004年 / 116卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(04)00046-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.

引用

页码：205 / 219

页数：15

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