Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression

被引：9

作者：

Sun, Zhen-Qiang ^{[1
]}

Chen, Chen ^{[1
]}

Zhou, Quan-Bo ^{[1
]}

Liu, Jin-Bo ^{[1
]}

Yang, Shuai-Xi ^{[1
]}

Li, Zhen ^{[1
]}

Ou, Chun-Lin ^{[2
]}

Sun, Xian-Tao ^{[1
]}

Wang, Gui-Xian ^{[1
]}

Song, Jun-Min ^{[1
]}

Zhang, Zhi-Yong ^{[1
]}

Yuan, Wei-Tang ^{[1
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Anorectal Surg, Zhengzhou 450052, Henan, Peoples R China

[2] Cent South Univ, Canc Res Inst, Changsha 410008, Hunan, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 57期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

long non-coding RNA; LINC00959; colorectal cancer; epithelial-mesenchymal transition; biomarker; EPITHELIAL-MESENCHYMAL-TRANSITION; CELL-PROLIFERATION; IDENTIFICATION; TUMORIGENESIS; METASTASIS; STATISTICS;

D O I：

10.18632/oncotarget.21171

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long non-coding RNAs (lncRNAs) are increasingly implicated in tumorigenesis and cancer progression. This study focused on the relationship between the lncRNA LINC00959 and colorectal cancer (CRC). We found that LINC00959 expression was lower in CRC tissues than normal colorectal mucosae. High LINC00959 expression was negatively associated with TNM stage, distant metastasis, and lymphatic metastasis, and correlated with a better prognosis in 87 CRC cases. In vitro, LINC00959 knockdown enhanced colon cancer cell proliferation, invasion, and migration; upregulated N-cadherin and vimentin; and downregulated E-cadherin and Caspase-3. LINC00959 overexpression produced the opposite effects. These data suggest that LINC00959 inhibits tumor cell invasion and migration by suppressing epithelial-mesenchymal transition and promotes apoptosis through Caspase-3. LINC00959 may be a tumor suppressor and useful prognostic biomarker in CRC.

引用

页码：97052 / 97060

页数：9

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