Hypoxia-Inducible Factor-1α is upregulated in Natural Killer cells by Interleukin-2 and hypoxia via PI3K/mTOR signaling pathway

被引:0
|
作者
Cluff, Emily R. [1 ]
Nolan, Joshua [1 ]
Collins, Cortney [1 ]
Varadaraj, Archana [1 ]
Rajasekaran, Narendiran [1 ]
机构
[1] No Arizona Univ, Flagstaff, AZ 86011 USA
来源
JOURNAL OF IMMUNOLOGY | 2019年 / 202卷 / 01期
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
194.37
引用
收藏
页数:3
相关论文
共 50 条
  • [1] Lysophosphatidic Acid Activates Telomerase in Ovarian Cancer Cells Through Hypoxia-Inducible Factor-1α and the PI3K Pathway
    Yang, Kun
    Zheng, Danhua
    Deng, Xiaoli
    Bai, Lin
    Xu, Yan
    Cong, Yu-Sheng
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2008, 105 (05) : 1194 - 1201
  • [2] Regulation and signaling pathway of hypoxia-inducible factor-1 activation
    Zhang, PH
    Chen, LY
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2002, 29 (06) : 863 - 867
  • [3] Hypoxia promotes the proliferation of MC3T3-E1 cells via the hypoxia-inducible factor-1α signaling pathway
    Wang, Lichao
    Wu, Buling
    Zhang, Yu
    Tian, Zhihui
    MOLECULAR MEDICINE REPORTS, 2015, 12 (04) : 5267 - 5273
  • [4] Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways
    Zhao, Zhan-Xue
    Li, Shuai
    Liu, Lin-Xun
    WORLD JOURNAL OF GASTROENTEROLOGY, 2024, 30 (21) : 2793 - 2816
  • [5] Inhibitors of hypoxia-inducible factor-1 signaling
    Belozerov, Vladimir E.
    Van Meir, Erwin G.
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2006, 7 (12) : 1067 - 1076
  • [6] Honokiol inhibits hypoxia-inducible factor-1 pathway
    Lan, Keng-Li
    Lan, Keng-Hsin
    Sheu, Meei-Ling
    Chen, Ming-Yuan
    Shih, Yi-Sheng
    Hsu, Fu-Chih
    Wang, Hong-Ming
    Liu, Ren-Shyan
    Yen, Sang-Hue
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2011, 87 (06) : 579 - 590
  • [7] Strongylophorines: Natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway
    Mohammed, Kaleem A.
    Jadulco, Raquel C.
    Bugni, Tim S.
    Harper, Mary Kay
    Sturdy, Megan
    Ireland, Chris M.
    JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (05) : 1402 - 1405
  • [8] Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis
    Alexandra Giatromanolaki
    Efthimios Sivridis
    Efstratios Maltezos
    Nick Athanassou
    Dimitrios Papazoglou
    Kevin C Gatter
    Adrian L Harris
    Michael I Koukourakis
    Arthritis Res Ther, 5
  • [9] Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells
    Emily Cluff
    Carina C. Magdaleno
    Emyly Fernandez
    Trenton House
    Srividya Swaminathan
    Archana Varadaraj
    Narendiran Rajasekaran
    Cancer Immunology, Immunotherapy, 2022, 71 : 1989 - 2005
  • [10] Hypoxia-inducible factor-1 alpha expression is induced by IL-2 via the PI3K/mTOR pathway in hypoxic NK cells and supports effector functions in NKL cells and ex vivo expanded NK cells
    Cluff, Emily
    Magdaleno, Carina C.
    Fernandez, Emyly
    House, Trenton
    Swaminathan, Srividya
    Varadaraj, Archana
    Rajasekaran, Narendiran
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2022, 71 (08) : 1989 - 2005