Insight into the Double-Edged Role of Ferroptosis in Disease

被引:22
作者
Zhang, Lei [1 ,2 ]
Jia, Ruohan [1 ,3 ]
Li, Huizhen [1 ,3 ]
Yu, Huarun [3 ]
Ren, Keke [3 ]
Jia, Shuangshuang [2 ]
Li, Yanzhang [2 ]
Wang, Qun [2 ]
机构
[1] Henan Univ, Henan Int Joint Lab Nucl Prot Regulat, Kaifeng 475004, Peoples R China
[2] Henan Univ, Sch Basic Med Sci, Kaifeng 475004, Peoples R China
[3] Henan Univ, Sch Clin Med, Kaifeng 475004, Peoples R China
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
ferroptosis; systemic diseases; ROS; inhibitors; inducers; GLUTATHIONE-PEROXIDASE; 4; CELL-DEATH; LIPID-PEROXIDATION; REGULATES FERROPTOSIS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; LIVER FIBROSIS; UNITED-STATES; CANCER;
D O I
10.3390/biom11121790
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson's disease, and Alzheimer's disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis.
引用
收藏
页数:20
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