New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression

被引：38

作者：

Liaw, Chih-Chuang ^{[1
,2
,4
]}

Yang, Yu-Liang ^{[1
,3
,4
]}

Lin, Chun-Kuang ^{[1
]}

Lee, Jin-Ching ^{[4
,5
]}

Liao, Wen-Ying ^{[6
]}

Shen, Chia-Ning ^{[6
]}

Sheu, Jyh-Horng ^{[1
,2
,4
]}

Wu, Shih-Hsiung ^{[1
,7
,8
,9
]}

机构：

[1] Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan

[3] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung, Taiwan

[6] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan

[7] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[8] Natl Taiwan Univ, Inst Biochem Sci, Taipei 106, Taiwan

[9] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 10期

关键词：

PHYSICOCHEMICAL PROPERTIES; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE; CELLS; COX-2;

D O I：

10.1021/acs.orglett.5b00739

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel meroterpenoids, yaminterritrems A (1) and B (2), were isolated from Aspergillus terreus collected from hot spring zones in Yang-Ming Mountain, Taiwan, and cultured at 40 degrees C. The structures of 1 and 2 were elucidated by NMR, MS spectral and X-ray crystallographic analyses. The biosynthetic route for 1 and 2 involving the conversion of the sesquiterpene with phenyl-alpha-pyrone is proposed. Besides, 2 exhibited a dose-dependent inhibitory effect on COX-2 expression in LPS-stimulated RAW264.7 macrophages.

引用

页码：2330 / 2333

页数：4

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