Familial Lateral Temporal Lobe Epilepsy Confirmed With Intracranial Electroencephalography and Successfully Treated by Surgery -Five Case Reports in One Family-

被引：6

作者：

Koizumi, Satoshi ^{[1
]}

Kawai, Kensuke ^{[1
]}

Asano, Shuichiro ^{[1
]}

Ueki, Keisuke ^{[1
]}

Suzuki, Ichiro ^{[1
]}

Saito, Nobuhito ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neurosurg, Bunkyo Ku, Tokyo 1139655, Japan

来源：

NEUROLOGIA MEDICO-CHIRURGICA | 2011年 / 51卷 / 08期

关键词：

temporal lobe epilepsy; epilepsy surgery; subdural electrode; familial epilepsy; autosomal dominant lateral temporal lobe epilepsy; HIPPOCAMPAL ATROPHY; GENETIC FEATURES; MUTATIONS; DEPTH; FOCI;

D O I：

10.2176/nmc.51.604

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Documentation of familial epilepsy is of paramount importance for identification of epilepsy-associated genes, elucidation of pathomechanisms of epilepsy, and development of treatment of epilepsy. We report a Japanese family with 5 members with lateral temporal lobe epilepsy beginning around the second decade of life. All seizures were intractable to medical treatment, and four patients underwent surgical treatment following long-term monitoring by intracranial electroencephalography with subdural electrodes, which revealed neocortical origins for the seizure. These four patients were successfully treated with surgery. The clinical features of this familial temporal lobe epilepsy seem to be different from those of previously reported types of familial temporal lobe epilepsy.

引用

页码：604 / 610

页数：7

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