Efficient access to multi-substituted 1-aminoisoquinolines via Rh(III)- catalyzed oxidative annulation of aminopyridine pivalamides with internal alkynes

被引：0

作者：

Gan, Xiaoting ^{[1
]}

Huang, Fen ^{[1
]}

Ren, Zhijun ^{[1
]}

Li, Bo ^{[2
]}

Chen, Shaojie ^{[1
]}

Luo, Wenkun ^{[1
]}

Zhou, Jun ^{[1
]}

机构：

[1] Changsha Univ Sci & Technol, Sch Chem & Chem Engn, Hunan Prov Key Lab Mat Protect Elect Power & Trans, Changsha 410114, Peoples R China

[2] Zhejiang NHU Co Ltd, Shaoxing 312500, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 103卷

基金：

中国国家自然科学基金;

关键词：

Rhodium; C-H activation; Annulation; Aminopyridine; Isoquinoline; C-H ACTIVATION; ONE-POT SYNTHESIS; ISOQUINOLINE DERIVATIVES; FUNCTIONALIZATION; RING; BENZANNULATION; PICOLINAMIDES; INHIBITORS; MULTIPLE; AMIDINES;

D O I：

10.1016/j.tetlet.2022.153970

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of multi-substituted 1-aminoisoquinolines from aminopyridine pivalamides with alkynes by Rh(III)-catalyzed C-H activation coupling has been investigated. This method proved to be tolerant of synthetically versatile functional groups, and provided access to a few highly substituted isoquinoline derivatives with remarkable fluorescence properties in moderate yields.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：7